典型文献
Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice
文献摘要：
Gynostemma pentaphyllum, also called "Southern Ginseng" in China, is a traditional Asian folk medicinal plant. Gypenosides (Gps) are the biologically active constituents of G. pentaphyllum, which have been reported with hypoglycemic activity. However, the underlying mechanisms are unclear. The effects of two Gps (Gp-I and Gp-II) on type 2 diabetic mellitus (T2DM) mice, induced by high-fat and high-sugar diet and streptozotocin, were evaluated to explore the mechanism of their hypoglycemic actions. Gps reduced fasting blood glucose and serum lipids, as well as significantly improved T2DM mice glucose tolerance and insulin resistance (IR). After Gps treatment, the severity of liver injury was reduced and liver glycogen content increased. In addition, Gps promoted the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), and downregulated the key proteins phosphoenolpyruvate carboxy kinase and glucose-6 phosphatase, in the AMPK signaling pathway. Thus, our study suggests that Gps mediate hepatic gluconeogenesis and improve IR via activating AMPK signaling pathway in T2DM mice.
文献关键词：
中图分类号：
作者姓名：
Mengxue Song;Dehong Tan;Bin Li;Yanqun Wang;Lin Shi
作者机构：
College of Food Science,Shenyang Agricultural University,Shenyang 110866,China;Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province,Shenyang Agricultural University,Shenyang 110866,China
文献出处：
引用格式：
[1]Mengxue Song;Dehong Tan;Bin Li;Yanqun Wang;Lin Shi-.Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice)[J].食品科学与人类健康（英文）,2022(05):1347-1354
A类：
Gypenoside,Gypenosides,Gps
B类：
ameliorates,insulin,resistance,hyperglycemia,via,AMPK,mediated,signaling,pathways,liver,type,diabetes,mellitus,mice,Gynostemma,pentaphyllum,also,called,Southern,Ginseng,China,traditional,Asian,folk,medicinal,plant,are,biologically,active,constituents,which,have,been,reported,hypoglycemic,activity,However,underlying,mechanisms,unclear,effects,two,II,diabetic,T2DM,induced,by,high,fat,sugar,diet,streptozotocin,were,evaluated,explore,their,actions,reduced,fasting,blood,glucose,serum,lipids,well,significantly,improved,tolerance,After,treatment,severity,injury,was,glycogen,content,increased,In,addition,promoted,phosphorylation,adenosine,monophosphate,activated,kinase,downregulated,key,proteins,phosphoenolpyruvate,carboxy,phosphatase,Thus,our,study,suggests,that,hepatic,gluconeogenesis,activating
AB值：
0.596808
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