典型文献
Fas -670 A/G polymorphism predicts prognosis of hepatocellular carcinoma after curative resection in Chinese Han population
文献摘要：
Background: Apoptosis, also called programmed cell death, is a genetically controlled process against hyperproliferation and malignancy. The Fas-Fas ligand (FasL) system is considered a major pathway for apoptosis in cells and tissues. Thus, this study aimed to investigate whether single nucleotide polymor- phisms (SNPs) in Fas and FasL gene may have effects on the recurrence and survival of patients with hepatocellular carcinoma (HCC) after curative hepatectomy.Methods: We investigated the relationship between Fas rs1800682, rs2234767 and FasL rs763110 poly- morphisms and recurrence-free survival (RFS) as well as overall survival (OS) in 117 Chinese Han patients with HCC who underwent hepatectomy. Results: In Kaplan-Meier survival analysis, only Fas rs1800682 (-670 A/G) was associated with RFS and OS. Compared with AA genotype, the AG/GG genotype was significantly associated with better RFS ( P = 0.008) and OS ( P = 0.020). Moreover, multivariate Cox regression analysis showed that Fas rs1800682 remained as a significant independent predictor of RFS for HCC patients with hepatectomy [AG/GG vs. AA: adjusted hazard ratio = 0.464, 95％ confidence interval: 0.275–0.782, P = 0.004], but was not an independent predictor of OS ( P = 0.395). Conclusions: This study demonstrated that Fas -670 G allele may play a protective role in the recurrence and survival of HCC patients with hepatectomy. Furthermore, Fas rs1800682 polymorphism might be a promising biomarker for HCC patients after hepatectomy.
文献关键词：
中图分类号：
作者姓名：
Xin-Yi Guo;Yi-Lin Xia;Zhi-Yang Li;Ran Li;Yang Fan;Wen-Mo Yao;Fei Liu
作者机构：
West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Liver Surgery&Liver Transplantation Center,West China Hospital,Sichuan University,Chengdu 610041,China
文献出处：
引用格式：
[1]Xin-Yi Guo;Yi-Lin Xia;Zhi-Yang Li;Ran Li;Yang Fan;Wen-Mo Yao;Fei Liu-.Fas -670 A/G polymorphism predicts prognosis of hepatocellular carcinoma after curative resection in Chinese Han population)[J].国际肝胆胰疾病杂志(英文版),2022(01):33-40
A类：
phisms,rs1800682,rs2234767,rs763110
B类：
polymorphism,predicts,prognosis,hepatocellular,carcinoma,after,curative,resection,Chinese,Han,population,Background,Apoptosis,also,called,programmed,death,genetically,controlled,process,against,hyperproliferation,malignancy,ligand,FasL,system,considered,major,pathway,apoptosis,cells,tissues,Thus,this,study,aimed,whether,single,nucleotide,SNPs,may,have,effects,recurrence,survival,patients,HCC,hepatectomy,Methods,We,investigated,relationship,between,morphisms,free,RFS,well,overall,OS,who,underwent,Results,In,Kaplan,Meier,analysis,only,was,associated,Compared,AA,genotype,AG,GG,significantly,better,Moreover,multivariate,Cox,regression,showed,that,remained,independent,predictor,adjusted,hazard,confidence,interval,but,Conclusions,This,demonstrated,allele,play,protective,role,Furthermore,might,promising,biomarker
AB值：
0.490726
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