典型文献
All about NASH:disease biology,targets,and opportunities on the road to NASH drugs
文献摘要：
When it comes to unmet medical needs,nonalcoholic steatohe-patitis(NASH),a progressive form of the nonalcoholic fatty liver disease(NAFLD),is definitely on the top of the list,affecting 1.5％-6.45％population and at least 100 million people world-wide.Over the past two decades,pharmaceutical and biotech companies around the globe have devoted extensive resources to the discovery and development of NASH drugs.Unfortunately,no NASH drug has been approved by FDA,EMA,or any other leading regulatory agencies as of today.The future for NASH drug discovery and development has faced tremendous uncer-tainty with capital investment into this field experiencing a"cold winter"since 2019.What are the biological basis and valid drug targets of NASH?What are the key regulatory issues?How to overcome the obstacles ahead on the road to the first NASH drug?In order to answer these questions,we invite ten experts and their colleagues to share their visions and insights into the challenges and opportunities of NASH drug discovery and development,from disease mechanism and origins,to therapeu-tic targets and diagnosis,and to treatment development and regulatory perspectives.
文献关键词：
中图分类号：
作者姓名：
H.Eric Xu;Jin-song Guo
作者机构：
Key Laboratory of Receptor Research,State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;DrugTimes Team,BioSeed(Shanghai)Biotechnology Co.,Ltd.,Shanghai 201203,China
文献出处：
引用格式：
[1]H.Eric Xu;Jin-song Guo-.All about NASH:disease biology,targets,and opportunities on the road to NASH drugs)[J].中国药理学报（英文版）,2022(05):1101-1102
A类：
steatohe,patitis
B类：
All,about,NASH,disease,biology,targets,opportunities,road,drugs,When,comes,unmet,medical,needs,nonalcoholic,progressive,form,fatty,liver,NAFLD,definitely,top,list,affecting,population,least,million,people,world,wide,Over,past,two,decades,pharmaceutical,biotech,companies,around,globe,have,devoted,extensive,resources,discovery,development,Unfortunately,has,been,approved,by,FDA,EMA,any,other,leading,regulatory,agencies,today,future,faced,tremendous,uncer,tainty,capital,investment,into,this,field,experiencing,cold,winter,since,What,biological,basis,valid,key,issues,How,overcome,obstacles,ahead,first,In,order,answer,these,questions,invite,experts,their,colleagues,share,visions,insights,challenges,from,mechanism,origins,therapeu,diagnosis,treatment,perspectives
AB值：
0.622244
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
