典型文献
Renin-angiotensin system antagonists and mortality due to pneumonia, influenza, and chronic lower respiratory disease in patients with hypertension
文献摘要：
BACKGROUND It is controversial whether angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEI/ARB) have a potentially beneficial role in the respiratory system. This study investigated the association between ACEI/ARB medications and respiratory-related mortality in hypertensive patients in a real-world nationally representative cohort. METHODS This was a retrospective analysis based on a prospective cohort study. A total of 10,530 patients with hypertension aged ≥ 20 years were included. The data was extracted from the US National Health and Nutrition Examination Survey during 1988–1994 and 1999–2006. The study was approved by the Institutional Review Boards. Moreover, inform concent was taken form all the participants. RESULTS Overall, 27.7％ (n = 2920) patients took ACEI/ARB agents. During a median follow-up of 12.4 years, 278 individuals died of respiratory disease, including chronic lower respiratory disease (n = 155) and influenza or pneumonia (n = 123). Com-pared with the patients without ACEI/ARB use, those taking ACEI/ARB were not associated with respiratory-specific mortality in a multivariable-adjusted Cox model. After 1: 1 matching, taking ACEI/ARB was also not related to respiratory mortality (Haz-ard ratio (HR) = 1.07, 95％ CI: 0.79–1.43), influenza- or pneumonia-related (HR = 1.00, 95％ CI: 0.65–1.54) and chronic pulmonary mortality (HR = 1.13, 95％ CI: 0.75–1.69). After separating ACEI and ARB from anti-hypertensive medications, those associations remained unchanged. CONCLUSIONS We discovered no significant link between ACEI or ARB medication and pulmonary-related mortality in hy-pertensive patients. In hypertensive patients, standard ACEI/ARB administration may have little effect on the respiratory system.
文献关键词：
中图分类号：
作者姓名：
Heng-Xuan CAI;Chen-Chen LIANG;Shan-Jie WANG;Jun-Chen GUO;Ye WANG;Bo YU;Xue-Qin GAO;Shao-Hong FANG
作者机构：
Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin,China;The Key Laboratory of Myocardial Ischemia,Chinese Ministry of Education,Harbin,China
文献出处：
引用格式：
[1]Heng-Xuan CAI;Chen-Chen LIANG;Shan-Jie WANG;Jun-Chen GUO;Ye WANG;Bo YU;Xue-Qin GAO;Shao-Hong FANG-.Renin-angiotensin system antagonists and mortality due to pneumonia, influenza, and chronic lower respiratory disease in patients with hypertension)[J].老年心脏病学杂志（英文版）,2022(07):511-521
A类：
concent,Haz,pertensive
B类：
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AB值：
0.515505
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