The association between blood eosinophil (EOS) counts and arterial/venous throm-bosis is unclear. We aim to explore whether EOS count is a risk factor for throm-bosis. We searched several databases and preprint platforms using core terms 'eosinophil', 'myocardial infarction', 'ischemic stroke', and 'venous thromboembo-lism' (VTE), among others. Studies comparing the odds ratios (ORs) or risk ratios (RRs) of EOSs with the abovementioned diseases were eligible. Overall, 22 studies were included. A high EOS count was associated with acute coronary artery throm-bosis events (OR: 1.23, 95％ CI: 1.15– 1.32), short-term cerebral infarction and mor-tality (RR: 2.87, 95％ CI: 1.49– 5.51). The short-term risk of VTE was more common in patients with EOS-related diseases (RR: 6.52, 95％ CI: 2.42– 17.54). For coronary artery disease, a high EOS count was a protective factor against 6-month to 1-year mortality (RR: 0.56, 95％ CI: 0.45– 0.69) but was associated with long-term mortal-ity (RR: 1.64, 95％ CI: 1.25– 2.14). Therefore, we conclude that for coronary artery thrombosis, EOS count is not associated with AMI events in general population. It may be associated with NSTEMI and STEMI in CAD patients, but more studies are needed to confirm this. In addition, EOS count is associated with an increased risk of both short-and long-term mortality but is not predictive of the composite end-points. For cerebral artery thrombosis, EOS count may be associated with cerebral infarction and could lead to an increased risk of poor short-term prognosis. For VTEs, EOS count was a risk factor for some patients, especially those with acute-phase EOS-related diseases.

Wei-Jie Xu;Shang Wang;Ping Yuan;Lan Wang;Jun-Xia Huang;Rong Jiang

Department of Clinical Laboratory,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China;Department of Cardio-Pulmonary Circulation,Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,China;Department of Hematology,Affiliated Hospital of Qingdao University,Qingdao,Shandong,China

动物模型与实验医学（英文）

[1]Wei-Jie Xu;Shang Wang;Ping Yuan;Lan Wang;Jun-Xia Huang;Rong Jiang-.Arterial and venous thromboembolism risk associated with blood eosinophils: A systematic review and meta-analysis)[J].动物模型与实验医学（英文）,2022(05):470-481

preprint,VTEs

Arterial,venous,thromboembolism,risk,associated,blood,eosinophils,systematic,review,meta,analysis,association,between,counts,arterial,unclear,We,aim,explore,whether,searched,several,databases,platforms,using,core,terms,myocardial,infarction,ischemic,stroke,among,others,Studies,comparing,odds,ratios,ORs,RRs,EOSs,abovementioned,diseases,were,eligible,Overall,studies,included,high,was,acute,coronary,artery,events,short,cerebral,more,common,patients,related,For,protective,against,month,year,mortality,but,long,Therefore,conclude,that,thrombosis,not,AMI,general,population,It,may,NSTEMI,CAD,are,needed,confirm,this,In,addition,increased,both,predictive,composite,end,points,could,lead,poor,prognosis,some,especially,those,phase

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