典型文献
Development and validation of a predictive model for endocervical curettage in patients referred for colposcopy:A multicenter retrospective diagnostic study in China
文献摘要：
Objective:This study aimed to develop a nomogram that can predict occult high-grade squamous intraepithelial lesions or worse(HSIL+)and determine the need for endocervical curettage(ECC)in patients referred for colposcopy.Methods:This retrospective multicenter study included 4,149 patients who were referred to any one of six tertiary hospitals in China for colposcopy between January 2020 and November 2021 because of abnormal screening results.ECC data were extracted from the medical records.Univariate and multivariate logistic regression analyses were performed to identify factors that could predict HSIL+on ECC.Patients were randomly assigned to a training set or to an internal validation set for performance and comparability testing.The model was externally validated and tested in patients from two additional hospitals.The nomogram was assessed in terms of discrimination and calibration and subjected to decision curve analysis.Results:HSIL+was found on ECC in 38.8％(n=388)of cases.Our predictive nomogram included age group,cytology,human papillomavirus(HPV)status,visibility of the cervix and colposcopic impression.The nomogram had good overall discrimination,which was internally validated[area under the receiver-operator characteristic(AUC),0.839;95％confidence interval(95％CI),0.773-0.904].In terms of external validation,the AUC was 0.843(95％CI,0.773-0.912)for the consecutive sample and 0.843(95％CI,0.783-0.902)for the comparative sample.Calibration analysis suggested good consistency between predicted and observed probabilities.Decision curve analysis suggested this nomogram would be clinically useful with almost the entire range of threshold probabilities.Conclusions:This internally and externally validated nomogram can be easily applied and incorporates multiple clinically relevant variables that can be used to identify patients with occult HSIL+who need ECC.
文献关键词：
中图分类号：
作者姓名：
Peng Xue;Bingrui Wei;Samuel Seery;Qing Li;Zichen Ye;Yu Jiang;Youlin Qiao
作者机构：
Department of Epidemiology and Biostatistics,School of Population Medicine and Public Health,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Faculty of Health and Medicine,Division of Health Research,Lancaster University,Lancaster,LA1 4YW,United Kingdom;Diagnosis and Treatment for Cervical Lesions Center,Shenzhen Maternity and Child Healthcare Hospital,Shenzhen 518028,China
文献出处：
引用格式：
[1]Peng Xue;Bingrui Wei;Samuel Seery;Qing Li;Zichen Ye;Yu Jiang;Youlin Qiao-.Development and validation of a predictive model for endocervical curettage in patients referred for colposcopy:A multicenter retrospective diagnostic study in China)[J].中国癌症研究（英文版）,2022(04):395-405
A类：
colposcopy,HSIL+on,HSIL+was,colposcopic,HSIL+who
B类：
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AB值：
0.531372
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