典型文献
Preoperative lymphocyte to C-reactive protein ratio as a new prognostic indicator in patients with resectable gallbladder cancer
文献摘要：
Background:Inflammation is often related to cancer,and several inflammatory scores have been estab-lished to predict the prognosis of various types of cancer.Our study aimed to determine the prognostic value of the preoperative lymphocyte to C-reactive protein ratio(LCR)for predicting postoperative out-comes in patients with resectable gallbladder cancer(GBC).Methods:A retrospective analysis of 104 GBC patients who received curative surgery at Xinhua Hospi-tal,Affiliated to Shanghai Jiao Tong University School of Medicine from January 2000 to December 2016 was performed.A time-dependent receiver operating characteristic curve was constructed to evaluate the accuracy of different markers.Univariate and multivariate Cox proportional hazard models were used to define factors associated with overall survival.Results:Among the assessed variables,the preoperative LCR showed the highest accuracy in predicting the overall survival of GBC patients(AUC:0.736).Decreased preoperative LCR was significantly associated with advanced tumor stage,including tumor invasion(P = 0.018),lymph node metastasis(P = 0.011)and TNM stage(P = 0.022).A low preoperative LCR(cutoff threshold = 145.5)was an independent risk factor for overall survival in patients with resectable GBC(P＜0.001).Conclusions:The preoperative LCR is a novel and valuable prognostic indicator of postoperative survival in patients with resectable GBC.
文献关键词：
中图分类号：
作者姓名：
Wen-Yan Yao;Xiang-Song Wu;Shi-Lei Liu;Zi-You Wu;Ping Dong;Wei Gong
作者机构：
Department of General Surgery,Xinhua Hospital,Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Shanghai Key Laboratory of Biliary Tract Disease Research,Shanghai 200092,China
文献出处：
引用格式：
[1]Wen-Yan Yao;Xiang-Song Wu;Shi-Lei Liu;Zi-You Wu;Ping Dong;Wei Gong-.Preoperative lymphocyte to C-reactive protein ratio as a new prognostic indicator in patients with resectable gallbladder cancer)[J].国际肝胆胰疾病杂志(英文版),2022(03):267-272
A类：
Hospi
B类：
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AB值：
0.577179
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