典型文献
Prognostic and incremental value of computed tomography-based radiomics from tumor and nodal regions in esophageal squamous cell carcinoma
文献摘要：
Objective:This study aimed to evaluate the prognostic value of preoperative radiomics and establish an integrated model for esophageal squamous cell cancer(ESCC).Methods:A total of 931 patients were retrospectively enrolled in this study(training cohort,n=624;validation cohort,n=307).Radiomics features were obtained by contrast-enhanced computed tomography(CT)before esophagectomy.A radiomics index was set based on features of tumor and reginal lymph nodes by using the least absolute shrinkage and selection operator(LASSO)Cox regression.Prognostic nomogram was built based on radiomics index and other independent risk factors.The prognostic value was assessed by using Harrell's concordance index,time-dependent receiver operating characteristics and Kaplan-Meier curves.Results:Twelve radiomic features from tumor and lymph node regions were identified to build a radiomics index,which was significantly associated with overall survival(OS)in both training cohort and validation cohort.The radiomics index was highly correlated with clinical tumor-node-metastasis(cTNM)and pathologic TNM(pTNM)stages,but it demonstrated a better prognostic value compared with cTNM stage and was almost comparable with pTNM stage.Multivariable Cox regression showed that the radiomics index was an independent prognostic factor.An integrated model was constructed based on gender,preoperative serum sodium concentration,pTNM and the radiomics index for clinical usefulness.The integrated model demonstrated discriminatory ability better compared with the traditional clinical-pathologic model and pTNM alone,indicating incremental value for prognosis.Conclusions:CT-based radiomics for primary tumor and reginal lymph nodes was sufficient in predicting OS for patients with ESCC.The integrated model demonstrated incremental value for prognosis and was robust for clinical applications.
文献关键词：
中图分类号：
作者姓名：
Bangrong Cao;Kun Mi;Wei Dai;Tong Liu;Tianpeng Xie;Qiang Li;Jinyi Lang;Yongtao Han;Lin Peng;Qifeng Wang
作者机构：
Radiation Oncology Key Laboratory of Sichuan Province Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China;Department of Biobank Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China;Department of Thoracic Surgery Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China;Department of Medical Imaging Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China;Department of Radiation Oncology,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,China
文献出处：
引用格式：
[1]Bangrong Cao;Kun Mi;Wei Dai;Tong Liu;Tianpeng Xie;Qiang Li;Jinyi Lang;Yongtao Han;Lin Peng;Qifeng Wang-.Prognostic and incremental value of computed tomography-based radiomics from tumor and nodal regions in esophageal squamous cell carcinoma)[J].中国癌症研究（英文版）,2022(02):71-82
A类：
reginal,radiomic
B类：
Prognostic,incremental,value,computed,tomography,radiomics,from,tumor,nodal,regions,esophageal,squamous,cell,carcinoma,Objective,This,study,aimed,evaluate,prognostic,preoperative,establish,integrated,model,cancer,ESCC,Methods,total,patients,were,retrospectively,enrolled,this,training,cohort,validation,Radiomics,features,obtained,by,contrast,enhanced,before,esophagectomy,was,set,lymph,nodes,using,least,absolute,shrinkage,selection,operator,LASSO,Cox,regression,nomogram,built,other,independent,risk,factors,assessed,Harrell,concordance,receiver,operating,characteristics,Kaplan,Meier,curves,Results,Twelve,identified,build,which,significantly,associated,overall,survival,OS,both,highly,correlated,clinical,metastasis,cTNM,pathologic,pTNM,stages,but,demonstrated,better,compared,almost,comparable,Multivariable,showed,that,An,constructed,gender,serum,sodium,concentration,usefulness,discriminatory,ability,traditional,alone,indicating,prognosis,Conclusions,primary,sufficient,predicting,robust,applications
AB值：
0.480571
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