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典型文献
High nuclear ABCG1 expression is a poor predictor for hepatocellular carcinoma patient survival
文献摘要:
Background:ATP-binding cassette transporter G1(ABCG1)regulates cellular cholesterol homeostasis and plays a significant role in tumor immunity.But,for hepatocellular carcinoma(HCC),the role of ABCG1 has not been investigated.Thus,the aim of this study was to evaluate the prognostic value and clinico-pathological significance of ABCG1 in HCC.Methods:One hundred and four adult patients with HCC were enrolled,and ABCG1 expression in paired HCC specimens was determined by immunohistochemistry.All these patients were stratified by ABCG1 expression,Kaplan-Meier analysis was used to compare the overall survival(OS)and recurrence-free sur-vival(RFS),and Cox regression analysis was used to determine independent predictors of tumor recur-rence.Results:Upregulation of ABCG1 was observed in HCC samples compared to matched tumor-adjacent tis-sues.Patients with high nuclear ABCG1 expression had lower OS and RFS(P=0.012 and P=0.020,respectively).High nuclear ABCG1 expression was related to larger tumor size(P=0.004)and tu-mor recurrence(P=0.027).Although ABCG1 was expressed in the cytoplasm,cytosolic expression could not predict the outcome in patients with HCC.A new stratification pattern was established based on the heterogenous ABCG1 expression pattern:high risk(Highnucleus/Lowcytoso1),moderate risk(Highnucleus/Highcyttosol or Lownucleus/Lowcytosol)and low risk(Lownucleus/Highcytosol).This ABCG1-based risk stratification could distinguish the different OS and RFS in patients with HCC.Multivariate Cox regression analysis indicated that ABCG1 high risk was an independent predictor of poor RFS(P=0.015).Conclusions:High nuclear ABCG1 expression indicates poor prognosis in patients with HCC.Asymmetric distribution of ABCG1 in the nucleus and cytoplasm may have an important role in tumor recurrence.
文献关键词:
作者姓名:
Bin Xi;Fang-Zhou Luo;Bin He;Fang Wang;Ze-Kuan Li;Ming-Chun Lai;Shu-Sen Zheng
作者机构:
Division of Hepatobiliary and Pancreatic Surgery,Department of Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Department of Radiotherapy,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Key Laboratory of Combined Multi-Organ Transplantation,Ministry of Public Health,Zhejiang University,Hangzhou 310003,China
引用格式:
[1]Bin Xi;Fang-Zhou Luo;Bin He;Fang Wang;Ze-Kuan Li;Ming-Chun Lai;Shu-Sen Zheng-.High nuclear ABCG1 expression is a poor predictor for hepatocellular carcinoma patient survival)[J].国际肝胆胰疾病杂志(英文版),2022(04):370-377
A类:
clinico,Highnucleus,Lowcytoso1,Highcyttosol,Lownucleus,Lowcytosol,Highcytosol
B类:
nuclear,ABCG1,expression,poor,hepatocellular,carcinoma,survival,Background,ATP,binding,cassette,transporter,regulates,cholesterol,homeostasis,plays,significant,role,tumor,immunity,But,HCC,has,not,been,investigated,Thus,aim,this,study,was,evaluate,prognostic,value,pathological,significance,Methods,One,hundred,four,adult,patients,were,enrolled,paired,specimens,determined,by,immunohistochemistry,All,these,stratified,Kaplan,Meier,analysis,used,overall,OS,recurrence,free,RFS,Cox,regression,independent,predictors,Results,Upregulation,observed,samples,compared,matched,adjacent,tis,sues,Patients,high,had,lower,respectively,related,larger,size,Although,expressed,cytoplasm,cytosolic,could,outcome,new,stratification,pattern,established,heterogenous,risk,moderate,This,distinguish,different,Multivariate,indicated,that,Conclusions,indicates,prognosis,Asymmetric,distribution,may,have,important
AB值:
0.420353
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