典型文献
Metabolic reprogramming and epigenetic modifications on the path to cancer
文献摘要：
Metabolic rewiring and epigenetic remodeling,which are closely linked and reciprocally regulate each other,are among the well-known cancer hallmarks.Recent evi-dence suggests that many metabolites serve as sub-strates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regional-ization of enzymes or metabolites.Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts,playing important roles in tumor progression.In this review,we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations,in particular the acety-lation and methylation of histone proteins and DNA.We also discuss other eminent metabolic modifications such as,succinylation,hydroxybutyrylation,and lacty-lation,and update the current advances in metabolism-and epigenetic modification-based therapeutic pro-spects in cancer.
文献关键词：
中图分类号：
作者姓名：
Linchong Sun;Huafeng Zhang;Ping Gao
作者机构：
Guangzhou First People's Hospital,School of Medicine,Institutes for Life Sciences,South China University of Technology,Guangzhou 510006,China;The First Affiliated Hospital of USTC,University of Science and Technology of China,Hefei 230027,China;CAS Centre for Excellence in Cell and Molecular Biology,the CAS Key Laboratory of Innate Immunity and Chronic Disease,School of Basic Medical Sciences,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China;School of Biomedical Sciences and Engineering,Guangzhou International Campus,South China University of Technology,Guangzhou 510006,China
文献出处：
引用格式：
[1]Linchong Sun;Huafeng Zhang;Ping Gao-.Metabolic reprogramming and epigenetic modifications on the path to cancer)[J].蛋白质与细胞,2022(12):877-919
A类：
immunosurveillance,acety,hydroxybutyrylation,lacty
B类：
Metabolic,reprogramming,epigenetic,modifications,path,cancer,rewiring,remodeling,which,are,closely,linked,reciprocally,regulate,each,other,among,well,known,hallmarks,Recent,dence,suggests,that,many,metabolites,serve,sub,strates,cofactors,chromatin,modifying,enzymes,consequence,translocation,spatial,regional,ization,Various,metabolic,alterations,also,reportedly,drive,immune,escape,impede,within,certain,contexts,playing,important,roles,tumor,progression,In,this,review,focus,how,cells,reshapes,particular,methylation,histone,proteins,We,discuss,eminent,such,succinylation,update,current,advances,metabolism,therapeutic,spects
AB值：
0.610524
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