典型文献
Low molecular weight heparin reduces arterial blood lactic acid content and increases estimated glomerular filtration rate in patients with moderate Covid-19 pneumonia
文献摘要：
Background::Coronavirus disease 2019 (Covid-19) remains a serious health threat worldwide. We aimed to investigate whether low molecular weight heparin (LMWH) can promote organ function recovery in moderate Covid-19 pneumonia patients.Methods::We initiated an LMWH protocol in Covid-19 patients with increased D-dimer, body mass index >30 kg/m
2 or a history of diabetes from January 18, 2020 at Shanghai Public Health Clinical Center. In this retrospective study, we assigned moderate Covid-19 pneumonia patients admitted between January 18th and April 18, 2020 receiving the LMWH protocol to the LMWH group. Moderate patients who met the inclusion criteria but did not receive LMWH protocol were included in the control group by 1:2 propensity score matching. General clinical information, indicators for renal function, arterial blood gas analyses, arterial blood lactic acid content (mmol/L), and coagulation indexes at 0 day, 3 days, 7 days, and 11 days after admission were recorded and compared between the two groups.
Results::There were 41 patients in the LMWH group and 82 patients in the control group. General information in both groups were similar. Compared to the control group, the arterial blood lactic acid content (mmol/L) at day 11 (1.3 [1.1, 1.7]
vs. 1.2 [0.9, 1.3],
P = 0.016) was reduced in the LMWH group. The estimated glomerular filtration rate (eGFR) in the LMWH group was higher than that in the control group at day 7 (108.54 [89.11, 128.17]
vs. 116.85 [103.39, 133.47],
P= 0.039) and day 11 (113.74 [94.49, 126.34]
vs. 128.31 [112.75, 144.12],
P = 0.003). The serum creatinine levels (Scr) in the LMWH group were lower than that in the control group at day 7 (62.13 [51.47, 77.64]
vs. 55.49 [49.50, 65.75],
P= 0.038) and day 11 (63.35 [50.17, 75.73]
vs. 51.62 [44.62, 61.24],
P = 0.005).
Conclusions::LMWH treatment can reduce arterial blood lactic acid levels and improve eGFR in moderate Covid-19 pneumonia patients. Randomized controlled trials are warranted to further investigate this issue.Trial registration::ChiCTR.org.cn, ChiCTR2000034796.
文献关键词：
Arterial blood lactic acid;Covid-19;Kidney function;LMWH
中图分类号：
作者姓名：
Ma Li;Zeng Yigang;Zhao Bing;Xu Lili;Li Jian;Zhu Tongyu;Mao Enqiang
作者机构：
Emergency Department of Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China;Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China;Clinical Research Center in Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
文献出处：
引用格式：
[1]Ma Li;Zeng Yigang;Zhao Bing;Xu Lili;Li Jian;Zhu Tongyu;Mao Enqiang-.Low molecular weight heparin reduces arterial blood lactic acid content and increases estimated glomerular filtration rate in patients with moderate Covid-19 pneumonia)[J].中华医学杂志（英文版）,2022(06):691-696
A类：
ChiCTR2000034796
B类：
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AB值：
0.471798
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