典型文献
High-fidelity carbon dots polarity probes:revealing the heterogeneity of lipids in oncology
文献摘要：
Polarity is an integral microenvironment parameter in biological systems closely associated with a multitude of cellular processes.Abnormal polarity variations accompany the initiation and development of pathophysiological processes.Thus,monitoring the abnormal polarity is of scientific and practical importance.Current state-of-the-art monitoring techniques are primarily based on fluorescence imaging which relies on a single emission intensity and may cause inaccurate detection due to heterogeneous accumulation of the probes.Herein,we report carbon dots(CDs)with ultra-sensitive responses to polarity.The CDs exhibit two linear relationships:one between fluorescence intensity and polarity and the other between polarity and the maximum emission wavelength.The emission spectrum is an intrinsic property of the probes,independent of the excitation intensity or probe concentration.These features enable two-color imaging/quantitation of polarity changes in lipid droplets(LDs)and in the cytoplasm via in situ emission spectroscopy.The probes reveal the polarity heterogeneity in LDs which can be applied to make a distinction between cancer and normal cells,and reveal the polarity homogeneity in cytoplasm.
文献关键词：
中图分类号：
作者姓名：
Jingyu Hu;Yuanqiang Sun;Xin Geng;Junli Wang;Yifei Guo;Lingbo Qu;Ke Zhang;Zhaohui Li
作者机构：
Colllege of Chemistry,Institute of Analytical Chemistry for Life Science,Zhengzhou Key Laboratory of Functional Nanomaterial and Medical Theranostic,Zhengzhou University,450001 Zhengzhou,China;Institute of Chemical Biology and Clinical Application at the First Affiliate Hospital,Zhengzhou University,450001 Zhengzhou,China;Department of Chemistry and Chemical Biology,Northeastern University,Boston,MA 02115,USA
文献出处：
引用格式：
[1]Jingyu Hu;Yuanqiang Sun;Xin Geng;Junli Wang;Yifei Guo;Lingbo Qu;Ke Zhang;Zhaohui Li-.High-fidelity carbon dots polarity probes:revealing the heterogeneity of lipids in oncology)[J].光：科学与应用（英文版）,2022(07):1555-1564
A类：
Polarity
B类：
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AB值：
0.571974
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