典型文献
Effects of T-2 Toxin Exposure on Bone Metabolism and Bone Development of Mice
文献摘要：
T-2 toxin is the most widespread mycotoxin in crops, feed and food, which poses a serious threat to body health. Bone is the main target tissue for T-2 toxin accumulation. Ingestion of food contaminated by T-2 toxin is the main cause of Kashin-Beck disease. However, the specific mechanism of bone damage caused by T-2 toxin is still unclear. In this study, a total of 40 male C57BL/6N mice were divided into four groups and orally treated with 0, 0.5, 1.0 and 2.0 mg ? kg-1 body weight T-2 toxin for 28 days. The results showed that exposure to T-2 toxin led to weight loss, bone mineral density reduction and femoral structural damage of mice. In addition, osteoblast-mediated bone formation was inhibited, and osteoclast-mediated bone resorption was enhanced. Meanwhile, the levels of bone metabolism-related hormones including parathyroid hormone, calcitonin and 1, 25-dihydroxyvitamin D3 were reduced. More importantly, it was found that the level of neuropeptide Y (a neurohormone) was decreased. These results provided a new perspetive for understanding the osteotoxicity of T-2 toxin.
文献关键词：
中图分类号：
作者姓名：
Cui Yi-long;Cao Zheng;Zhang Jian;Song Miao;Li Yan-fei
作者机构：
College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China
文献出处：
引用格式：
[1]Cui Yi-long;Cao Zheng;Zhang Jian;Song Miao;Li Yan-fei-.Effects of T-2 Toxin Exposure on Bone Metabolism and Bone Development of Mice)[J].东北农业大学学报（英文版）,2022(01):89-96
A类：
Ingestion,neurohormone,perspetive,osteotoxicity
B类：
Effects,Toxin,Exposure,Bone,Metabolism,Development,Mice,most,widespread,mycotoxin,crops,feed,food,which,poses,serious,threat,body,health,main,target,tissue,accumulation,contaminated,by,Kashin,Beck,disease,However,specific,mechanism,bone,damage,caused,still,unclear,this,study,total,male,C57BL,6N,mice,were,divided,into,four,groups,orally,treated,weight,days,results,showed,that,exposure,led,loss,mineral,density,reduction,femoral,structural,addition,osteoblast,mediated,formation,was,inhibited,osteoclast,resorption,enhanced,Meanwhile,levels,metabolism,related,hormones,including,parathyroid,calcitonin,dihydroxyvitamin,D3,reduced,More,importantly,found,neuropeptide,decreased,These,provided,new,understanding
AB值：
0.619601
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