典型文献
NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis
文献摘要：
Nuclear receptor subfamily 4 group A1(NR4A1)is an orphan nuclear receptor,which is expressed in the majority of cells.NR4A1 expression in peripheral blood mononuclear cells is low during the preclinical stage of multiple sclerosis.Knockout of the Nr4a1 gene in mice can aggravate the symptoms of experimental autoimmune encephalomyelitis(EAE),which is an animal model of multiple sclerosis.In this study,we intragastrically administered the NR4A1 agonist cytosporone B(Csn-B)to mice after inducing EAE.After treatment with Csn-B,the clinical symptoms in the EAE mice were substantially attenuated compared with that in PBS-treated control mice.The percentages of CD4+T cells and F4/80+cells in the central nervous system were decreased.In addition,interferon-y and interleukin-17 production by proinflammatory Th1/Th17 cells in the central nervous system and interferon-y levels in splenocytes were decreased after Csn-B treatment.These findings suggest that the NR4A1 agonist Csn-B can alleviate nerve injury after EAE induction,and,therefore,may be useful as a potential treatment for multiple sclerosis.
文献关键词：
中图分类号：
作者姓名：
Hai-Zhen Yu;Bing-Qing Zhu;Lin Zhu;Shuo Li;Li-Mei Wang
作者机构：
Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,China
文献出处：
引用格式：
[1]Hai-Zhen Yu;Bing-Qing Zhu;Lin Zhu;Shuo Li;Li-Mei Wang-.NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis)[J].中国神经再生研究（英文版）,2022(12):2765-2770
A类：
cytosporone,Nr4a1,80+cells
B类：
NR4A1,agonist,attenuates,neuroinflammation,mouse,model,multiple,sclerosis,Nuclear,receptor,subfamily,group,orphan,which,expressed,majority,expression,peripheral,blood,mononuclear,low,during,preclinical,stage,Knockout,gene,mice,can,aggravate,symptoms,experimental,autoimmune,encephalomyelitis,EAE,animal,In,this,study,intragastrically,administered,Csn,after,inducing,After,treatment,were,substantially,attenuated,compared,that,PBS,treated,control,percentages,CD4+T,F4,central,nervous,system,decreased,addition,interferon,interleukin,production,by,proinflammatory,Th17,levels,splenocytes,These,findings,suggest,alleviate,nerve,injury,induction,therefore,may,be,useful,potential
AB值：
0.512971
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
