典型文献
Immunoregulatory polysaccharides from Apocynum venetum L. flowers stimulate phagocytosis and cytokine expression via activating the NF-Κb/MAPK signaling pathways in RAW264.7 cells
文献摘要：
Two immunomodulatory polysaccharides (Vp2a-Ⅱ and Vp3) were isolated and identified from Apocynum venetum L. flowers, and their innate immune-stimulating functions and working mechanisms were evaluated in RAW264.7 cells. Both the level of released nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) mRNA were significantly enhanced in the RAW264.7 macrophages cells treated by Vp2a-Ⅱ and Vp3. Vp2a-Ⅱ (100–800 μg/mL) and Vp3 (400 μg/mL) could significantly increase the phagocytic activity of RAW264.7 cells and the secretion and mRNA expression of TNF-α and IL-6 in a concentration-dependent manner through affecting mitogen-activated protein kinase (MAPK) activity and nuclear factor κB (NF-κB) nuclear translocation. Vp2a-Ⅱ might activate the MAPK signaling pathways and induce the nuclear translocation of NF-κB p65, whilst Vp3 likely activated the NF-κB and MAPK signaling pathways without influencing the p38 MAPK route.
文献关键词：
中图分类号：
作者姓名：
Honglin Wang;Changyang Ma;Dongxiao Sun-Waterhouse;Jinmei Wang;Geoffrey Ivan Neil Waterhouse;Wenyi Kang
作者机构：
National R&D Center for Edible Fungus Processing Technology,Henan University,Kaifeng 475004,China;Functional Food Engineering Technology Research Center,Kaifeng 475004,China;School of Chemical Sciences,University of Auckland,Auckland 1142,New Zealand;Joint International Research Laboratory of Food&Medicine Resource Function,Kaifeng 475004,China
文献出处：
引用格式：
[1]Honglin Wang;Changyang Ma;Dongxiao Sun-Waterhouse;Jinmei Wang;Geoffrey Ivan Neil Waterhouse;Wenyi Kang-.Immunoregulatory polysaccharides from Apocynum venetum L. flowers stimulate phagocytosis and cytokine expression via activating the NF-Κb/MAPK signaling pathways in RAW264.7 cells)[J].食品科学与人类健康（英文）,2022(04):806-814
A类：
Immunoregulatory,Vp2a
B类：
polysaccharides,from,Apocynum,venetum,flowers,stimulate,phagocytosis,cytokine,expression,via,activating,MAPK,signaling,pathways,RAW264,cells,Two,immunomodulatory,Vp3,were,isolated,identified,their,innate,immune,stimulating,functions,working,mechanisms,evaluated,Both,level,released,nitric,oxide,inducible,synthase,iNOS,significantly,enhanced,macrophages,treated,by,could,increase,phagocytic,activity,secretion,concentration,dependent,manner,through,affecting,mitogen,activated,protein,kinase,nuclear,translocation,might,induce,p65,whilst,likely,without,influencing,p38,route
AB值：
0.50987
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
