典型文献
Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling
文献摘要：
Objective: To explore the impact of fucoxanthin on oxidized low-density lipoprotein (OxLDL)-induced stress and inflammation in human endothelial cells and its underlying mechanisms.Methods: HUVECs were treated with OxLDL and/or fucoxanthin for a range of time points and concentrations. We evaluated the effects of fucoxanthin on OxLDL-induced HUVECs using the MTT assay, reactive oxygen species accumulation assay, ELISA, RT-PCR, immunofluorescence, and Western blotting. Results: Fucoxanthin enhanced the cell viability in a dose dependent manner after OxLDL exposure. Furthermore, fucoxanthin pretreatment significantly decreased OxLDL-induced reactive oxygen species production and prevented the activation of the nuclear factor kappa-B pathway, which led to substantial suppression of pro-inflammatory gene expressions. OxLDL-induced upregulation of interleukin-6, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin-1β, monocyte chemotactic protein-1, cyclooxygenase-1, and tumor necrosis factor-α was significantly reduced by fucoxanthin. Conclusions: Fucoxanthin can inhibit OxLDL-induced vascular inflammation and oxidative stress in HUVECs by targeting Nrf2 signaling pathways.
文献关键词：
中图分类号：
作者姓名：
Peramaiyan Rajendran;Abdullah M AlZahrani
作者机构：
Department of Biological Sciences,College of Science,King Faisal University,Al Ahsa 31982,Saudi Arabia
文献出处：
引用格式：
[1]Peramaiyan Rajendran;Abdullah M AlZahrani-.Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling)[J].亚太热带生物医学杂志（英文版）,2022(05):207-215
A类：
Fucoxanthin
B类：
suppresses,OxLDL,induced,inflammation,activation,Nrf2,inhibition,signaling,Objective,To,explore,impact,fucoxanthin,oxidized,low,density,lipoprotein,stress,human,endothelial,cells,its,underlying,mechanisms,Methods,HUVECs,were,treated,range,points,concentrations,evaluated,effects,using,MTT,assay,reactive,species,accumulation,immunofluorescence,blotting,Results,enhanced,viability,dose,dependent,manner,after,exposure,Furthermore,pretreatment,significantly,decreased,production,prevented,nuclear,kappa,which,led,substantial,suppression,inflammatory,gene,expressions,upregulation,interleukin,intercellular,adhesion,molecule,vascular,monocyte,chemotactic,cyclooxygenase,tumor,necrosis,was,reduced,by,Conclusions,oxidative,targeting,pathways
AB值：
0.523167
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