典型文献
Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-κB signaling
文献摘要：
Objective:To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa.Methods:The crude polysaccharide from roots of B.rapa(BRP)was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis.Results:Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity,including increasing production of nitric oxide(NO),tumor necrosis factor α(TNFα)and upregulating mRNA levels of inducible NO synthase(iNOS)and TNFα.Furthermore,modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B(NF-κB).Conclusion:The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases.
文献关键词：
中图分类号：
作者姓名：
Weiwei Guo;Qianxiao Zhang;Yu Du;Junting Guo;Tingting Zhao;Liping Bai;Xiqiang An
作者机构：
NHC Key Laboratory of Biotechnology of Antibiotics,CAMS Key Laboratory of Synthetic Biology for Drug Innovation,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;Key Laboratory for Uighur Medicine,Xinjiang Institute of Materia Medica,Urumqi 830004,China;Department of Chinese Materia Medica,Xinjiang Medical University,Urumqi 830054,China
文献出处：
引用格式：
[1]Weiwei Guo;Qianxiao Zhang;Yu Du;Junting Guo;Tingting Zhao;Liping Bai;Xiqiang An-.Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-κB signaling)[J].中草药（英文版）,2022(01):90-96
A类：
BRP
B类：
Immunomodulatory,activity,polysaccharides,from,Brassica,rapa,by,activating,Akt,signaling,Objective,To,investigate,immunomodulatory,roots,Methods,crude,was,extracted,purified,further,active,fraction,BRT,inducing,macrophage,phagocytosis,Results,Effects,RAW264,cells,demonstrated,that,behaved,better,phagocytic,capacity,had,potent,including,increasing,production,nitric,oxide,tumor,necrosis,upregulating,levels,inducible,synthase,iNOS,Furthermore,modulation,indicated,mediated,via,activation,nuclear,kappa,Conclusion,beneficial,effects,could,used,immunotherapeutic,adjuvant,treatment,inflammatory,diseases
AB值：
0.621642
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