典型文献
Application of zebrafish in the study of the gut microbiome
文献摘要：
Zebrafish ( Danio rerio ) have attracted much attention over the past decade as a reli-able model for gut microbiome research. Owing to their low cost, strong genetic and development coherence, efficient preparation of germ- free (GF) larvae, availability in high- throughput chemical screening, and fitness for intravital imaging in vivo, ze-brafish have been extensively used to investigate microbiome- host interactions and evaluate the toxicity of environmental pollutants. In this review, the advantages and disadvantages of zebrafish for studying the role of the gut microbiome compared with warm- blooded animal models are first summarized. Then, the roles of zebrafish gut microbiome on host development, metabolic pathways, gut- brain axis, and im-mune disorders and responses are addressed. Furthermore, their applications for the toxicological assessment of aquatic environmental pollutants and exploration of the molecular mechanism of pathogen infections are reviewed. We highlight the great po-tential of the zebrafish model for developing probiotics for xenobiotic detoxification, resistance against bacterial infection, and disease prevention and cure. Overall, the zebrafish model promises a brighter future for gut microbiome research.
文献关键词：
中图分类号：
作者姓名：
Xiaoting Zhong;Jinglin Li;Furong Lu;Jingjing Zhang;Lianxian Guo
作者机构：
Dongguan Key Laboratory of Environmental Medicine,School of Public Health,Guangdong Medical University,Dongguan,China;Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Disease,Guangdong Medical University,Zhanjiang,China;The Marine Biomedical Research Institute of Guangdong Zhanjiang,Zhanjiang,China;Dongguan Innovation Institute,Guangdong Medical University,Dongguan,China
文献出处：
引用格式：
[1]Xiaoting Zhong;Jinglin Li;Furong Lu;Jingjing Zhang;Lianxian Guo-.Application of zebrafish in the study of the gut microbiome)[J].动物模型与实验医学（英文）,2022(04):323-336
A类：
intravital,brafish,blooded
B类：
Application,zebrafish,gut,microbiome,Zebrafish,Danio,rerio,have,attracted,much,attention,over,past,decade,reli,able,research,Owing,their,low,cost,strong,genetic,development,coherence,efficient,preparation,germ,free,GF,larvae,availability,throughput,chemical,screening,fitness,imaging,vivo,been,extensively,used,investigate,host,interactions,evaluate,toxicity,environmental,pollutants,In,this,disadvantages,studying,compared,warm,animal,models,first,summarized,Then,roles,metabolic,pathways,brain,axis,mune,disorders,responses,addressed,Furthermore,applications,toxicological,assessment,aquatic,exploration,molecular,mechanism,pathogen,infections,reviewed,We,highlight,great,tential,developing,probiotics,xenobiotic,detoxification,resistance,against,bacterial,disease,prevention,cure,Overall,promises,brighter,future
AB值：
0.608524
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
