典型文献
The role of genotype and diet in shaping gut microbiome in a genetic vitamin A deficient mouse model
文献摘要：
Multifactors have been reported to affect the gut microbiome,including genotype,age,diet,and nutrition.However,few reports have investigated the relative capacity of different factors to shape the gut micro-biome in a single study.Our design used a genetic vitamin A-deficient mouse model,the Rbp4-/-mouse,feeding with the low vitamin A diets at different ages of initiation(4 or 7 weeks)for 28 days.Fecal samples were collected for bacterial profiling at seven time points after diet controlling.With Rbp4 depletion,Akkermansia decreased and Bacteroides increased,whereas Desulfovibrio,Barnesiella,Clostridium_XIVa,and Lactobacillus fluctuated.The bacterial community swiftly adjusted with the vitamin A-deficient diet administration and gradually changed(e.g.,decrease of Barnesiella and increase of Desulfovibrio).Age exerted a relatively weaker but long-last influence.At an earlier age to feed a vitamin A-deficient diet,a higher microbial dysbiosis index will be valued.Of note,the shaping effects of diet and age on the bacterial community varied with the difference of genotype,which might indicate a greater role of genotype than diet and age in shaping the gut microbiome.
文献关键词：
中图分类号：
作者姓名：
Jun Xu;Jie-Ni Zhang;Bo-Hui Sun;Qing Liu;Juan Ma;Qian Zhang;Yong-Xin Liu;Ning Chen;Feng Chen
作者机构：
Department of Gastroenterology,Peking University People's Hospital,Beijing 100044,China;Clinical Center of Immune-Mediated Digestive Diseases,Peking University People's Hospital,Beijing 100044,China;Institute of Clinical Molecular Biology&Central Laboratory,Peking University People's Hospital,Beijing 100044,China;Department of Orthodontics,Peking University School of Stomatology,Beijing 100081,China;Central Laboratory,Peking University School of Stomatology,Beijing 100081,China;CAS Center for Excellence in Biotic Interactions,Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Jun Xu;Jie-Ni Zhang;Bo-Hui Sun;Qing Liu;Juan Ma;Qian Zhang;Yong-Xin Liu;Ning Chen;Feng Chen-.The role of genotype and diet in shaping gut microbiome in a genetic vitamin A deficient mouse model)[J].遗传学报,2022(02):155-164
A类：
Multifactors,Rbp4,XIVa
B类：
role,genotype,shaping,gut,microbiome,genetic,vitamin,deficient,mouse,model,have,been,reported,affect,including,nutrition,However,few,reports,investigated,capacity,different,shape,single,study,Our,design,used,feeding,low,diets,ages,initiation,weeks,days,Fecal,samples,were,collected,bacterial,profiling,seven,points,after,controlling,With,depletion,Akkermansia,decreased,Bacteroides,increased,whereas,Desulfovibrio,Barnesiella,Clostridium,Lactobacillus,fluctuated,community,swiftly,adjusted,administration,gradually,changed,Age,exerted,relatively,weaker,but,long,last,influence,At,earlier,higher,microbial,dysbiosis,will,valued,Of,note,effects,varied,difference,which,might,indicate,greater,than
AB值：
0.523197
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
