典型文献
Zebrafish facilitates drug screening:potential of 3-deoxy-andrographoside from Chuanxinlian(Herba Andrographitis Paniculatae)as an anti-inflammatory agent
文献摘要：
OBJECTIVE:To systematically evaluate the in vivo anti-inflammatory potential of diterpene lactones from Chuanxinlian(Herba Andrographitis Paniculatae)(AP).METHODS:We firstly adopted zebrafish,a novel and ideal animal model for high-throughput drug screening,to investigate the in vivo anti-inflammatory activities of 17 diterpene lactones isolated from AP.RESULTS:The results showed that most of diterpene lactones displayed significant anti-inflammatory effects in lipopolysaccharide microinjection-,copper sulfate exposure-or tail transection-induced zebrafish inflammation models.Moreover,diterpene lactone 3-deoxy-andrographoside(AP-5)was firstly found to attenuate inflammatory responses,which was closely associated with the myeloid differentiation primary response 88/nuclear factor-kappa B and signal transducer and activator of transcription 3 pathways.CONCLUSION:Our research sheds light on the inestimable roles of zebrafish in high-throughput drug screening,elucidates the potent inhibitory effects of diterpene lactones against inflammation and indicates that AP-5 may serve as a potential alternative agent for the treatment of inflammatory diseases.
文献关键词：
中图分类号：
作者姓名：
HE Xuemei;XIAO Junjie;FAN Chunlin;LU Zibin;CAO Huihui;YU Linzhong;ZHENG Yuanru;LIU Junshan
作者机构：
Third Level Research Laboratory of State Administration of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics,Guangzhou 510515,China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou 510632,China;School of Pharmacy,Guangdong Pharmaceutical university,Guangzhou 510006,China;Department of Pharmacy,Zhujiang Hospital,Southern Medical University,Guangzhou 510515,China
文献出处：
引用格式：
[1]HE Xuemei;XIAO Junjie;FAN Chunlin;LU Zibin;CAO Huihui;YU Linzhong;ZHENG Yuanru;LIU Junshan-.Zebrafish facilitates drug screening:potential of 3-deoxy-andrographoside from Chuanxinlian(Herba Andrographitis Paniculatae)as an anti-inflammatory agent)[J].中医杂志（英文版）,2022(05):749-757
A类：
andrographoside,Chuanxinlian,Andrographitis,Paniculatae,inestimable
B类：
Zebrafish,facilitates,drug,screening,potential,deoxy,from,Herba,anti,inflammatory,agent,OBJECTIVE,To,systematically,evaluate,vivo,diterpene,lactones,AP,METHODS,We,firstly,adopted,zebrafish,novel,ideal,animal,high,throughput,investigate,activities,isolated,RESULTS,results,showed,that,most,displayed,significant,effects,lipopolysaccharide,microinjection,copper,sulfate,exposure,tail,transection,induced,inflammation,models,Moreover,was,found,attenuate,responses,which,closely,associated,myeloid,differentiation,primary,nuclear,kappa,signal,transducer,activator,transcription,pathways,CONCLUSION,Our,research,sheds,light,roles,elucidates,inhibitory,against,indicates,may,serve,alternative,treatment,diseases
AB值：
0.517572
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