典型文献
Generation of ring-shaped human iPSC-derived functional heart microtissues in a M?bius strip configuration
文献摘要：
Although human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)have been used for disease modeling and drug discovery,clinically relevant three-dimensional(3D)functional myocardial micro tissues are lacking.Here,we developed a novel ring-shaped cardiac microtissue comprised of chamber-specific tissues to achieve a geometrically non-orientable ventricular myocardial band,similar to a Mobius loop.The ring-shaped cardiac tissue was constructed of hiPSC-CMs and human cardiac fibroblasts(hCFs)through a facile cellular self-assembly approach.It exhibited basic anatomical structure,positive cardiac troponin T(cTnT)immunostaining,regular calcium transients,and cardiac-like mechanical strength.The cardiac rings can be self-assembled and scaled up into various sizes with outstanding stability,suggesting their potential for precise therapy,pathophysiological investigation,and large-scale drug screening.
文献关键词：
中图分类号：
作者姓名：
Yan Xu;Jingqi Qi;Wenyan Zhou;Xing Liu;Longbo Zhang;Xudong Yao;Hongwei Wu
作者机构：
Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China;Zhejiang University-University of Edinburgh Institute,Haining 314400,China;Xiangya Hospital,Central South University,Changsha 410008,China;Department of Neurosurgery,School of Medicine,Yale University,New Haven,CT,USA;International Institutes of Medicine,The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu 322000,China
文献出处：
引用格式：
[1]Yan Xu;Jingqi Qi;Wenyan Zhou;Xing Liu;Longbo Zhang;Xudong Yao;Hongwei Wu-.Generation of ring-shaped human iPSC-derived functional heart microtissues in a M?bius strip configuration)[J].生物设计与制造（英文）,2022(04):687-699
A类：
microtissues,microtissue,Mobius,hCFs
B类：
Generation,shaped,human,derived,functional,heart,strip,configuration,Although,induced,pluripotent,stem,cardiomyocytes,hiPSC,CMs,have,been,used,disease,modeling,drug,discovery,clinically,relevant,three,dimensional,myocardial,are,lacking,Here,we,developed,novel,cardiac,comprised,chamber,specific,achieve,geometrically,orientable,ventricular,band,similar,loop,was,constructed,fibroblasts,through,facile,cellular,self,assembly,approach,It,exhibited,basic,anatomical,structure,positive,troponin,cTnT,immunostaining,regular,calcium,transients,like,mechanical,strength,rings,can,assembled,scaled,up,into,various,sizes,outstanding,stability,suggesting,their,potential,precise,therapy,pathophysiological,investigation,large,screening
AB值：
0.66309
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
