典型文献
Methods of screening,monitoring and management of cardiac toxicity induced by chemotherapeutics
文献摘要：
Cardiac toxicity is one of the most common side effects of anticancer drugs.Cardiac toxicity results dys-function of heart including hypotension,heart failure,and even cause death in extreme cases.The po-tential risk of cardiotoxicity is a huge concern in chemotherapeutics mediated cancer treatment.The in-dividual with any pre-existing cardiac issues are excluded from clinical trials due to the potential risk of cardiotoxicity.Because of the potential cardiotoxicity,there is an emerging need for alternatives of some very potent anticancer drugs(doxorubicin/DOX,5-fluorouracil/5FU,trastuzumab).While a patient is be-ing treated with anticancer drugs,early blood screening,biomarker detection,and careful monitoring of cardiac functions are necessary to be able to avoid any irreversible cardiac damage.Therefore,early detec-tion methodology to monitor cardiotoxicity in real-time,and a drug formulation that prevent interaction between drug and cardiac cell,seemingly have potential to mitigate the risk.In this review,we have summarized the cardiotoxicity of the most used anticancer drugs,their pathophysiology and some of the conventional and newer screening methods available to manage an individual patient in clinic.We have also incorporated our perspective on how a rationale designing of biomolecules can be used to overcome the cardiotoxicity generated chemotherapeutics.
文献关键词：
中图分类号：
作者姓名：
Humayra Afrin;Christiancel Joseph Salazar;Mohsin Kazi;Syed Rizwan Ahamad;Majed Alharbi;Md Nurunnabi
作者机构：
Environmental Science&Engineering,University of Texas at El Paso,El Paso,TX 79965,United States;Border Biomedical Research Center,University of Texas at El Paso,El Paso,TX 79965,United States;Department of Pharmaceutical Sciences,School of Pharmacy,University of Texas at El Paso,El Paso,TX 79902,United States;Department of Pharmaceutics,College of Pharmacy,King Saud University,Riyadh 11451,Kingdom of Saudi Arabia;Central Laboratory,Department of Pharmaceutical Chemistry,College of Pharmacy,King Saud University,Riyadh 11451,Kingdom of Saudi Arabia;Department of Biomedical Engineering,University of Texas at El Paso,El Paso,TX 79965,United States
文献出处：
引用格式：
[1]Humayra Afrin;Christiancel Joseph Salazar;Mohsin Kazi;Syed Rizwan Ahamad;Majed Alharbi;Md Nurunnabi-.Methods of screening,monitoring and management of cardiac toxicity induced by chemotherapeutics)[J].中国化学快报（英文版）,2022(06):2773-2782
A类：
5FU
B类：
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AB值：
0.51355
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