典型文献
Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury
文献摘要：
Neurotrophic factors,currently administered orally or by intravenous drip or intramuscular injection,are the main method for the treatment of peripheral nerve crush injury.However,the low effective drug concentration arriving at the injury site results in unsatisfactory outcomes.Therefore,there is an urgent need for a treatment method that can increase the effective drug concentration in the injured area.In this study,we first fabricated a gelatin modified by methacrylic anhydride hydrogel and loaded it with vascular endothelial growth factor that allowed the controlled release of the neurotrophic factor.This modified gelatin exhibited good physical and chemical properties,biocompatibility and supported the adhesion and proliferation of RSC96 cells and human umbilical vein endothelial cells.When injected into the epineurium of crushed nerves,the composite hydrogel in the rat sciatic nerve crush injury model promoted nerve regeneration,functional recovery and vascularization.The results showed that the modified gelatin gave sustained delivery of vascular endothelial growth factors and accelerated the repair of crushed peripheral nerves.
文献关键词：
中图分类号：
作者姓名：
Wanlin Xu;Yifan Wu;Hao Lu;Yun Zhu;Jinhai Ye;Wenjun Yang
作者机构：
Department of Oral and Maxillofacial-Head and Neck Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine;College of Stomatology,Shanghai Jiao Tong University;National Center for Stomatology;National Clinical Research Center for Oral Diseases;Shanghai Key Laboratory of Stomatology,Shanghai,China;Jiangsu Key Laboratory of Oral Diseases,Department of Oral and Maxillofacial Surgery,The Affiliated Stomatological Hospital of Nanjing Medical University,Nanjing,Jiangsu Province,China
文献出处：
引用格式：
[1]Wanlin Xu;Yifan Wu;Hao Lu;Yun Zhu;Jinhai Ye;Wenjun Yang-.Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury)[J].中国神经再生研究（英文版）,2022(09):2064-2071
A类：
epineurium
B类：
Sustained,delivery,endothelial,growth,mediated,by,bioactive,methacrylic,anhydride,hydrogel,accelerates,peripheral,regeneration,after,injury,Neurotrophic,factors,currently,administered,orally,intravenous,drip,intramuscular,injection,main,method,treatment,However,effective,drug,concentration,arriving,results,unsatisfactory,outcomes,Therefore,there,urgent,need,that,can,increase,injured,area,In,this,study,first,fabricated,gelatin,modified,loaded,allowed,controlled,release,neurotrophic,This,exhibited,good,physical,chemical,properties,biocompatibility,supported,adhesion,proliferation,RSC96,cells,human,umbilical,vein,When,injected,into,crushed,nerves,composite,sciatic,model,promoted,functional,recovery,vascularization,showed,gave,sustained,accelerated,repair
AB值：
0.559654
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
