典型文献
Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats
文献摘要：
Exosomes derived from mesenchymal stem cells are of therapeutic interest because of their important role in intracellular communication and biological regulation.On the basis of previously studied nerve conduits,we designed a polydopamine-modified chitin conduit loaded with mesenchymal stem cell-derived exosomes that release the exosomes in a sustained and stable manner.In vitro experiments revealed that rat mesenchymal stem cell-derived exosomes enhanced Schwann cell proliferation and secretion of neurotrophic and growth factors,increased the expression of Jun and Sox2 genes,decreased the expression of Mbp and Krox20 genes in Schwann cells,and reprogrammed Schwann cells to a repair phenotype.Furthermore,mesenchymal stem cell-derived exosomes promoted neurite growth of dorsal root ganglia.The polydopamine-modified chitin conduits loaded with mesenchymal stem cell-derived exosomes were used to bridge 2 mm rat sciatic nerve defects.Sustained release of exosomes greatly accelerated nerve healing and improved nerve function.These findings confirm that sustained release of mesenchymal stem cell-derived exosomes loaded into polydopamine-modified chitin conduits promotes the functional recovery of injured peripheral nerves.
文献关键词：
中图分类号：
作者姓名：
Ci Li;Song-Yang Liu;Meng Zhang;Wei Pi;Bo Wang;Qi-Cheng Li;Chang-Feng Lu;Pei-Xun Zhang
作者机构：
Department of Orthopedics and Trauma,Peking University People's Hospital,Beijing,China;Key Laboratory of Trauma and Neural Regeneration,Ministry of Education,Beijing,China;National Center for Trauma Medicine,Beijing,China;Department of Orthopedics,Beijing Jishuitan Hospital,Beijing,China
文献出处：
引用格式：
[1]Ci Li;Song-Yang Liu;Meng Zhang;Wei Pi;Bo Wang;Qi-Cheng Li;Chang-Feng Lu;Pei-Xun Zhang-.Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats)[J].中国神经再生研究（英文版）,2022(09):2050-2057
A类：
Krox20
B类：
Sustained,release,exosomes,loaded,into,polydopamine,modified,chitin,conduits,promotes,peripheral,regeneration,rats,Exosomes,derived,from,mesenchymal,stem,cells,are,therapeutic,interest,because,their,important,role,intracellular,communication,biological,regulation,On,basis,previously,studied,designed,that,sustained,stable,manner,In,vitro,experiments,revealed,enhanced,Schwann,proliferation,secretion,neurotrophic,growth,factors,increased,expression,Jun,Sox2,genes,decreased,Mbp,reprogrammed,repair,phenotype,Furthermore,promoted,neurite,dorsal,root,ganglia,were,used,bridge,sciatic,defects,greatly,accelerated,healing,improved,These,findings,confirm,functional,recovery,injured,nerves
AB值：
0.493378
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
