典型文献
Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury
文献摘要：
Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation through regulating microglial phenotypes and promoting nerve injury repair.However,the underlying molecular mechanism remains unclear.In this study,we investigated the mechanism by which exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation.Our in vitro co-culture experiments showed that bone marrow mesenchymal stem cells and their exosomes promoted the polarization of activated BV2 microglia to their anti-inflammatory phenotype,inhibited the expression of proinflammatory cytokines,and increased the expression of anti-inflammatory cytokines.Our in vivo experiments showed that tail vein injection of exosomes reduced cell apoptosis in cortical tissue of mouse models of traumatic brain injury,inhibited neuroinflammation,and promoted the transformation of microglia to the anti-inflammatory phenotype.We screened some microRNAs related to neuroinflammation using microRNA sequencing and found that microRNA-181b seemed to be actively involved in the process.Finally,we regulated the expression of miR181b in the brain tissue of mouse models of traumatic brain injury using lentiviral transfection.We found that miR181b overexpression effectively reduced apoptosis and neuroinflamatory response after traumatic brain injury and promoted the transformation of microglia to the anti-inflammatory phenotype.The interleukin 10/STAT3 pathway was activated during this process.These findings suggest that the inhibitory effects of exosomes derived from bone marrow mesenchymal stem cells on neuroinflamation after traumatic brain injury may be realized by the action of miR181b on the interleukin 10/STAT3 pathway.
文献关键词：
中图分类号：
作者姓名：
Liang Wen;Ya-Dong Wang;Dong-Feng Shen;Pei-Dong Zheng;Meng-Di Tu;Wen-Dong You;Yuan-Run Zhu;Hao Wang;Jun-Feng Feng;Xiao-Feng Yang
作者机构：
The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang Province,China;Department of Intensive Care Unit,The First Hospital of Jiaxing,Jiaxing,Zhejiang Province,China;Department of Neurosurgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China
文献出处：
引用格式：
[1]Liang Wen;Ya-Dong Wang;Dong-Feng Shen;Pei-Dong Zheng;Meng-Di Tu;Wen-Dong You;Yuan-Run Zhu;Hao Wang;Jun-Feng Feng;Xiao-Feng Yang-.Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury)[J].中国神经再生研究（英文版）,2022(12):2717-2724
A类：
miR181b,neuroinflamatory,neuroinflamation
B类：
Exosomes,derived,from,bone,marrow,mesenchymal,stem,cells,neuroinflammation,after,traumatic,brain,injury,can,through,regulating,microglial,phenotypes,promoting,nerve,repair,However,underlying,molecular,mechanism,remains,unclear,In,this,study,investigated,by,which,exosomes,Our,vitro,culture,experiments,showed,that,their,promoted,polarization,activated,BV2,anti,inhibited,proinflammatory,cytokines,increased,vivo,tail,vein,injection,reduced,apoptosis,cortical,tissue,mouse,models,transformation,We,screened,microRNAs,related,using,sequencing,found,seemed,be,actively,involved,process,Finally,regulated,lentiviral,transfection,overexpression,effectively,response,interleukin,STAT3,pathway,was,during,These,findings,suggest,inhibitory,effects,may,realized,action
AB值：
0.404796
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
