典型文献
Tracing PRX1+cells during molar formation and periodontal ligament reconstruction
文献摘要：
Neural crest-derived mesenchymal stem cells (MSCs) are known to play an essential function during tooth and skeletal development. PRX1+cells constitute an important MSC subtype that is implicated in osteogenesis. However, their potential function in tooth development and regeneration remains elusive. In the present study, we first assessed the cell fate of PRX1+cells during molar development and periodontal ligament (PDL) formation in mice. Furthermore, single-cell RNA sequencing analysis was performed to study the distribution of PRX1+cells in PDL cells. The behavior of PRX1+cells during PDL reconstruction was investigated using an allogeneic transplanted tooth model. Although PRX1+cells are spatial specific and can differentiate into almost all types of mesenchymal cells in first molars, their distribution in third molars is highly limited. The PDL formation is associated with a high number of PRX1+cells;during transplanted teeth PDL reconstruction, PRX1+cells from the recipient alveolar bone participate in angiogenesis as pericytes. Overall, PRX1+cells are a key subtype of dental MSCs involved in the formation of mouse molar and PDL and participate in angiogenesis as pericytes during PDL reconstruction after tooth transplantation.
文献关键词：
中图分类号：
作者姓名：
Xuyan Gong;Han Zhang;Xiaoqiao Xu;Yunpeng Ding;Xingbo Yang;Zhiyang Cheng;Dike Tao;Congjiao Hu;Yaozu Xiang;Yao Sun
作者机构：
Department of Implantology,School&Hospital of Stomatology,Tongji University,Shanghai,China;Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai,China;Shanghai East Hospital,School of Life Sciences and Technology,Tongji University,Shanghai,China
文献出处：
引用格式：
[1]Xuyan Gong;Han Zhang;Xiaoqiao Xu;Yunpeng Ding;Xingbo Yang;Zhiyang Cheng;Dike Tao;Congjiao Hu;Yaozu Xiang;Yao Sun-.Tracing PRX1+cells during molar formation and periodontal ligament reconstruction)[J].国际口腔科学杂志（英文版）,2022(01):51-59
A类：
PRX1+cells,molars
B类：
Tracing,during,formation,periodontal,ligament,reconstruction,Neural,crest,derived,mesenchymal,stem,MSCs,are,known,play,essential,function,tooth,skeletal,development,constitute,important,subtype,that,implicated,osteogenesis,However,their,potential,regeneration,remains,elusive,In,present,study,first,assessed,fate,PDL,mice,Furthermore,single,sequencing,analysis,was,performed,distribution,behavior,investigated,using,allogeneic,transplanted,model,Although,spatial,specific,can,differentiate,into,almost,types,third,highly,limited,associated,number,teeth,from,recipient,alveolar,bone,participate,angiogenesis,pericytes,Overall,key,dental,involved,mouse,after,transplantation
AB值：
0.45783
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
