典型文献
Effectiveness of ChAdOx1 nCoV-19 coronavius vaccine in preventing severe disease and mortality during the second wave of pandemic: A case-case analysis from a tertiary care center in South India
文献摘要：
Objective: To determine the real-world effectiveness of the ChAdOx1 nCoV-19 coronavirus vaccine in preventing severe disease and mortality due to COVID-19. Methods: A case-case design was used to estimate the effect of the ChAdOx1 nCoV-19 coronavirus vaccine on severe SARS-CoV-2 outcomes in individuals aged 40 years and above. Cases (n=200) were COVID-19 patients admitted to intensive care unit (ICU) or who died. Controls (n=223) were those with mild COVID-19, fit for home isolation. The logistic regression model was used to estimate adjusted vaccine effectiveness for full vaccination (two doses ≥14 d) and partial vaccination status (one dose ≥14 d or two doses <14 d). Results: The proportion of fully vaccinated individuals was significantly lower among cases (12, 6.0％) compared to controls (30, 13.5％). The adjusted effectiveness of a full dose of ChAdOx1 nCoV-19 coronavirus vaccine in preventing ICU admission or death was 81.9％ (95％ CI: 61.3％-91.6％, P=0.001). Subgroup analysis restricted to age group, sex, and comorbidities found that ChAdOx1 nCoV-19 coronavirus vaccine had a significant positive effect in all subgroups and categories. Conclusion: COVID-19 vaccination reduces ICU admissions or death. Therefore, increased vaccine uptake may reduce the severity of the pandemic, more so in the elderly and those with comorbidities.
文献关键词：
中图分类号：
作者姓名：
Priyanka Rajmohan;Unnikrishnan Uttumadathil Gopinathan;Nada Parvin Ashraf Saudha;Maria Jose;Lucy Raphael;Joe Thomas
作者机构：
Department of Community Medicine,Jubilee Mission Medical College and Research Institute,Thrissur,Kerala,India;Department of Pharmacology,Jubilee Mission Medical College and Research Institute,Thrissur,Kerala,India
文献出处：
引用格式：
[1]Priyanka Rajmohan;Unnikrishnan Uttumadathil Gopinathan;Nada Parvin Ashraf Saudha;Maria Jose;Lucy Raphael;Joe Thomas-.Effectiveness of ChAdOx1 nCoV-19 coronavius vaccine in preventing severe disease and mortality during the second wave of pandemic: A case-case analysis from a tertiary care center in South India)[J].急性病杂志（英文版）,2022(05):188-193
A类：
ChAdOx1,coronavius
B类：
Effectiveness,nCoV,vaccine,preventing,severe,disease,mortality,during,second,wave,pandemic,analysis,from,tertiary,care,center,South,India,Objective,To,determine,real,world,effectiveness,coronavirus,due,Methods,design,was,used,estimate,SARS,outcomes,individuals,aged,years,above,Cases,were,patients,admitted,intensive,unit,ICU,who,died,Controls,those,mild,fit,home,isolation,logistic,regression,model,adjusted,vaccination,two,doses,partial,status,one,Results,proportion,fully,vaccinated,significantly,lower,among,cases,compared,controls,death,Subgroup,restricted,sex,comorbidities,found,that,had,positive,all,subgroups,categories,Conclusion,reduces,admissions,Therefore,increased,uptake,may,severity,more,elderly
AB值：
0.495141
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
