Vaccination is a major achievement that has become an effective prevention strategy against infectious diseases and active control of emerging pathogens worldwide. In response to the coronavirus disease 2019 (COVID-19) pandemic, several diverse vaccines against severe acute respiratory syndrome coronavirus 2 have been developed and deployed for use in a large number of individuals, and have been reported to protect against symptomatic COVID-19 cases and deaths. However, the application of vaccines has a series of limitations, including protective failure for variants of concern, unavailability of individuals due to immune deficiency, and the disappearance of immune protection for increasing infections in vaccinated individuals. These aspects raise the question of how to modulate the immune system that contributes to the COVID-19 vaccine protective effects. Herbal medicines are widely used for their immune regulatory abilities in clinics. More attractively, herbal medicines have been well accepted for their positive role in the COVID-19 prevention and suppression through regulation of the immune system. This review presents a brief overview of the strategy of COVID-19 vaccination and the response of the immune system to vaccines, the regulatory effects and mechanisms of herbal medicine in immune-related macrophages, natural killer cells, dendritic cells, and lymphocytes T and B cells, and how they help vaccines work. Later in the article, the potential role and application of herbal medicines in the most recent COVID-19 vaccination are discussed. This article provides new insights into herbal medicines as promising alternative supplements that may benefit from COVID-19 vaccination.

State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China;Institute of Traditional Chinese Medicine,Tianjin University ofTraditional Chinese Medicine,Tianjin,China;Faculty of Pharmacy,Mahasarakham University,Mahasarakham,Thailand;Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China;Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Ministry of Education,Tianjin University of Traditional Chinese Medicine,Tianjin,China;Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin,China

[1]Xuan Li;Nuttapong Wichai;Jiabao Wang;Xiuping Liu;Huimin Yan;Yu Wang;Mingchi Luo;Shengyuan Zhou;Kai Wang;Lin Li;Lin Miao-.Regulation of innate and adaptive immunity using herbal medicine: benefits for the COVID-19 vaccination)[J].针灸和草药（英文）,2022(03):196-206

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