典型文献
Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies
文献摘要：
Unprecedented advances have been achieved in hepatobiliary cancer treatment with immune checkpoint blockade(ICB).However,the efficacy of ICB in patients with hepatobiliary malignancies is still limited.Resistance to immunotherapies is often orchestrated by complicated tumor-host-microenvironment inter-actions but could also occur after initial efficacy,mostly when only partial responses are obtained.Clarifi-cation of cancer-resistance mechanisms will be beneficial to provide the rationale for the administration of personalized drugs.Here,we review the factors related to resistance to immune-targeted therapies in hepatobiliary malignancies and discuss the potential strategies for overcoming resistance and future directions of immunotherapy development.
文献关键词：
中图分类号：
作者姓名：
Jia Xiong;Qing-Qing Wang
作者机构：
Institute of Immunology,Zhejiang University School of Medicine,Hangzhou 310058,China;The Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province,Hangzhou 310058,China
文献出处：
引用格式：
[1]Jia Xiong;Qing-Qing Wang-.Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies)[J].国际肝胆胰疾病杂志(英文版),2022(05):430-439
A类：
Clarifi
B类：
Mechanisms,strategies,overcome,immunotherapy,resistance,hepatobiliary,malignancies,Unprecedented,advances,have,been,achieved,cancer,treatment,immune,checkpoint,blockade,ICB,However,efficacy,patients,still,limited,Resistance,immunotherapies,often,orchestrated,by,complicated,tumor,host,microenvironment,inter,actions,but,could,also,occur,after,initial,mostly,when,only,partial,responses,are,obtained,cation,mechanisms,will,beneficial,provide,rationale,administration,personalized,drugs,Here,review,factors,related,targeted,discuss,potential,overcoming,future,directions,development
AB值：
0.660328
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