典型文献
MicroRNAs as potential therapeutic targets for pancreatic cancer
文献摘要：
Pancreatic cancer is one of the most aggressive malignancies. The poor prognosis of pancreatic cancer patients is mainly attributed to low diagnostic rate at the early stage, highly aggressive nature coupled with the inadequate efficacy of current chemotherapeutic regimens. Novel therapeutic strategies are urgently needed for pancreatic cancer. MicroRNAs (miRNAs) play an important regulatory role in key processes of cancer development. The aberrant expression of miRNAs is often involved in the initiation, progression, and metastasis of pancreatic cancer. The discovery of tumor suppressor miRNAs provides prospects for the development of a novel treatment strategy for pancreatic cancer. We reviewed recent progress on the understanding of the role of miRNAs in pancreatic cancer, highlighted the efficient application of miRNAs-based therapies for pancreatic cancer in animal models and clinical trials, and proposed future prospects. This review focuses on the promise of integrating miRNAs into the treatment of pancreatic cancer and provides guidance for the development of precision medicine for pancreatic cancer.
文献关键词：
Pancreatic cancer;MicroRNA;MicroRNA carriers;Precision medicine
中图分类号：
作者姓名：
Chu Xiangyu;Wei Dan;Liu Xinxin;Long Di;Tian Xiaodong;Yang Yinmo
作者机构：
Department of General Surgery, Peking University First Hospital, Beijing 100034, China
文献出处：
引用格式：
[1]Chu Xiangyu;Wei Dan;Liu Xinxin;Long Di;Tian Xiaodong;Yang Yinmo-.MicroRNAs as potential therapeutic targets for pancreatic cancer)[J].中华医学杂志（英文版）,2022(01):4-10
A类：
B类：
MicroRNAs,potential,targets,pancreatic,cancer,Pancreatic,one,most,aggressive,malignancies,poor,prognosis,patients,mainly,attributed,low,diagnostic,early,stage,highly,nature,coupled,inadequate,efficacy,current,chemotherapeutic,regimens,Novel,strategies,are,urgently,needed,miRNAs,play,important,regulatory,role,key,processes,development,aberrant,expression,often,involved,initiation,progression,metastasis,discovery,tumor,suppressor,provides,prospects,novel,treatment,strategy,We,reviewed,recent,understanding,highlighted,efficient,application,therapies,animal,models,clinical,trials,proposed,future,This,focuses,promise,integrating,into,guidance,precision,medicine,carriers,Precision
AB值：
0.54901
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
