典型文献
Association of C-reactive Protein with Cardiovascular Outcomes: A Mendelian Randomization Study in the Japanese Population
文献摘要：
Objective Traditional epidemiological studies have shown that C-reactive protein (CRP) is associated with the risk of cardiovascular diseases (CVDs). However, whether this association is causal remains unclear. Therefore, Mendelian randomization (MR) was used to explore the causal relationship of CRP with cardiovascular outcomes including ischemic stroke, atrial fibrillation, arrhythmia and congestive heart failure. Methods We performed two-sample MR by using summary-level data obtained from Japanese Encyclopedia of Genetic association by Riken (JENGER), and we selected four single-nucleotide polymorphisms associated with CRP level as instrumental variables. MR estimates were calculated with the inverse-variance weighted (IVW), penalized weighted median and weighted median. MR-Egger regression was used to explore pleiotropy. Results No significant causal association of genetically determined CRP level with ischemic stroke, atrial fibrillation or arrhythmia was found with all four MR methods (all Ps > 0.05). The IVW method indicated suggestive evidence of a causal association between CRP and congestive heart failure (OR:1.337, 95％ CI: 1.005–1.780, P = 0.046), whereas the other three methods did not. No clear pleiotropy or heterogeneity were observed. Conclusions Suggestive evidence was found only in analysis of congestive heart failure; therefore, further studies are necessary. Furthermore, no causal association was found between CRP and the other three cardiovascular outcomes.
文献关键词：
中图分类号：
作者姓名：
CAO Ming Yang;LIU Di;ZHANG Xiao Yu;TIAN Qiu Yue;ZHANG Qun;WANG You Xin
作者机构：
Beijing Key Laboratory of Clinical Epidemiology,School of Public Health,Capital Medical University,Beijing 100069,China;Centre for Biomedical Information Technology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong,China;Department of Anesthesiology,Sanbo Brain Hospital,Capital Medical University,Beijing 100093,China;Chinese Center for Disease Control and Prevention,Beijing 102206,China;Centre for Precision Medicine,School of Medical and Health Sciences,Edith Cowan University,Perth 60127,Australia
文献出处：
引用格式：
[1]CAO Ming Yang;LIU Di;ZHANG Xiao Yu;TIAN Qiu Yue;ZHANG Qun;WANG You Xin-.Association of C-reactive Protein with Cardiovascular Outcomes: A Mendelian Randomization Study in the Japanese Population)[J].生物医学与环境科学（英文版）,2022(02):126-132,中插11-中插15
A类：
Randomization,Riken,JENGER,pleiotropy,Suggestive
B类：
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AB值：
0.533427
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