Objective:To evaluate the existing randomized controlled trials(RCTs)for evidence of the efficacy and safety of head acupuncture(HA)plus Schuell's language rehabilitation(SLR)in post-stroke aphasia.Methods:Seven databases including Embase,PubMed,Cochrane Library,Technology Periodical Database,the China National Knowledge Infrastructure,SinoMed and Wanfang Data Information Site were searched for RCTs published from database inception until November 14,2021.RCTs that compared HA plus SLR with sham(or blank)control,acupuncture therapy alone,certain language rehabilitation therapy alone or other therapies for post-stroke aphasia were included.Data were extracted and assessed,and the quality of RCTs was evaluated.Fixed-effects model was used,with meta-influence analysis,meta-regression,and regression-based sub-group analyses applied for exploration of heterogeneity.Publication bias was estimated by funnel plots and Egger's tests.Results:A total of 32 RCTs with 1,968 patients were included and 51 comparisons were conducted classified as types of strokes and aphasia.(1)For patients with aphasia after ischemic stroke,HA plus PSA showed significantly higher accumulative markedly effective rate[relative risk(RR)=1.55,95％confidence interval(CI):1.19-2.02,I2=0％]and accumulative effective rate(RR=1.22,95％CI:1.09-1.36,I2=0％).(2)For patients with comprehensive types of stroke,HA plus PSA was more effective in increasing recovery rate(RR=1.89,95％CI:1.39-2.56,I2=0％),accumulative markedly effective rate(RR=1.53,95％CI:1.36-1.72,I2=9％)and accumulative effective rate(RR=1.14,95％CI:1.09-1.19,I2=34％).(3)For patients with aphasia after stroke,HA plus PSA was superior to PSA alone with statistical significance in increasing recovery rate(RR=2.08,95％CI:1.24-3.46,I2=0％),accumulative markedly effective rate(RR=1.49,95％CI:1.24-1.78,I2=0％)and accumulative effective rate(RR=1.15,95％CI:1.06-1.24,I2=39％).(4)For patients with multiple types of aphasia,HA plus PSA also demonstrated significantly higher recovery rate(RR=1.86,95％CI:1.28-2.72,I2=0％),accumulative markedly effective rate(RR=1.55,95％CI:1.35-1.78,I2=22％),and accumulative effective rate(RR=1.17,95％CI:1.11-1.23,I2=41％).(5)For patients with motor aphasia after ischemic stroke,compared with PSA alone,HA plus PSA showed significantly higher accumulative markedly effective rate(RR=1.38,95％CI:1.06-1.79,I2=0％)and accumulative effective rate(RR=1.20,95％CI:1.05-1.37,I2=0％).Meta-regression analyses were performed without significant difference,and publication bias was found in some comparisons.Conclusion:HA plus SLR was significantly associated with better language ability and higher effective rate for patients with post-stroke aphasia,and HA should be operated cautiously especially during acupuncture at eye and neck.(Registration No.CRD42020154475)

FU Qin-wei;LIU Miao;ZHANG Lan-zhi;YANG Hui;ZHANG Le-qi;YANG Sha-sha;XIE Yan;WAN Xin-xin;TANG Yong;ZHANG Qin-xiu

Department of Otolaryngology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu(610075),China;Department of Gastroenterology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu(610075),China;Department of Medical Cosmetology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu(610075),China;Department of Endocrinology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu(610075),China;OCD Institute,McLean Hospital,Boston(02346),USA;Mental Health Counseling,Lynch School of Education,Boston College,Boston(02346),USA;Department of Otolaryngology,The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang(550005),China;Sydney School of Education and Social Work,The University of Sydney,Sydney(2006),Australia;Acupuncture and Tuina School,Chengdu University of Traditional Chinese Medicine,Chengdu(610075),China;School of Medical and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu(611137),China;World Health Organization Collaborating Centre(WHOCC)-CHN-56,Chengdu(611137),China

中国结合医学杂志（英文版）

[1]FU Qin-wei;LIU Miao;ZHANG Lan-zhi;YANG Hui;ZHANG Le-qi;YANG Sha-sha;XIE Yan;WAN Xin-xin;TANG Yong;ZHANG Qin-xiu-.Head Acupuncture Plus Schuell's Language Rehabilitation for Post-Stroke Aphasia:A Systematic Review and Meta-Analysis of 32 Randomized Controlled Trials)[J].中国结合医学杂志（英文版）,2022(08):743-752

Periodical,CRD42020154475

Head,Acupuncture,Plus,Schuell,Language,Rehabilitation,Post,Stroke,Aphasia,Systematic,Review,Analysis,Randomized,Controlled,Trials,Objective,To,existing,randomized,controlled,trials,RCTs,evidence,efficacy,safety,head,acupuncture,HA,plus,language,rehabilitation,SLR,post,aphasia,Methods,Seven,databases,including,Embase,Cochrane,Library,Technology,Database,China,National,Knowledge,Infrastructure,SinoMed,Wanfang,Information,Site,were,searched,published,from,inception,until,November,that,compared,sham,blank,therapy,alone,certain,other,therapies,included,extracted,assessed,quality,was,evaluated,Fixed,effects,model,used,meta,influence,analysis,regression,sub,group,analyses,applied,exploration,heterogeneity,Publication,bias,estimated,by,funnel,plots,Egger,tests,Results,total,patients,comparisons,conducted,classified,types,strokes,For,after,ischemic,PSA,showed,significantly,higher,accumulative,markedly,effective,relative,risk,RR,confidence,interval,I2,comprehensive,more,increasing,recovery,superior,statistical,significance,multiple,also,demonstrated,motor,performed,without,difference,publication,found,some,Conclusion,associated,better,ability,should,operated,cautiously,especially,during,eye,neck,Registration

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