典型文献
Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population
文献摘要：
Objective The association between neutrophil-to-lymphocyte ratio (NLR) with subclinicalmacrovascular and microvascular diseases has been less investigated. We sought to examine theassociation between NLR and new-onset subclinical macrovascular and microvascular abnormalities inthe Chinese population. Methods From a community cohort, we included 6,430 adults aged ≥ 40 years without subclinical macrovascular and microvascular diseases at baseline. We measured subclinical macrovascular andmicrovascular abnormalities separately using the ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and albuminuria. Results During a mean follow-up of 4.3 years, 110 participants developed incident abnormal ABI, 746 participants developed incident elevated baPWV, and 503 participants developed incident albuminuria. Poisson regression analysis indicated that NLR was significantly associated with an increased risk of new-onset abnormal ABI, elevated baPWV, and albuminuria. Compared to overweight/obese participants, we found a much stronger association between NLR and subclinical vascular abnormalities in participantswith normal weight. Furthermore, we found an interaction between the NLR and body mass index (BMI) on the risk of new-onset abnormal ABI (P for interaction: 0.01). Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in theChinese population. Furthermore, in participants with normal weight, the association between NLR and subclinical vascular abnormalities was much stronger.
文献关键词：
中图分类号：
作者姓名：
WANG Jia Lu;CAO Qiu Yu;XIN Zhuo Jun;LIU Shan Shan;XU Min;WANG Tian Ge;LU Jie Li;CHEN Yu Hong;WANG Shuang Yuan;ZHAO Zhi Yun;XU Yu;NING Guang;WANG Wei Qing;BI Yu Fang;LI Mian
作者机构：
Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,RuijinHospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Shanghai NationalClinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of theNational Health Commission of the PR China,Shanghai Key Laboratory for Endocrine Tumor,State Key Laboratoryof Medical Genomics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
文献出处：
引用格式：
[1]WANG Jia Lu;CAO Qiu Yu;XIN Zhuo Jun;LIU Shan Shan;XU Min;WANG Tian Ge;LU Jie Li;CHEN Yu Hong;WANG Shuang Yuan;ZHAO Zhi Yun;XU Yu;NING Guang;WANG Wei Qing;BI Yu Fang;LI Mian-.Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population)[J].生物医学与环境科学（英文版）,2022(01):4-12
A类：
Macrovascular,subclinicalmacrovascular,theassociation,andmicrovascular,participantswith,theChinese
B类：
Association,between,Neutrophil,lymphocyte,Ratio,New,onset,Subclinical,Microvascular,Diseases,Population,Objective,neutrophil,ratio,NLR,diseases,has,been,less,investigated,We,sought,examine,new,abnormalities,inthe,population,Methods,From,community,cohort,included,adults,aged,years,without,baseline,measured,separately,using,ankle,brachial,ABI,pulse,wave,velocity,baPWV,albuminuria,Results,During,mean,follow,up,developed,incident,elevated,Poisson,regression,analysis,indicated,that,was,significantly,associated,increased,risk,Compared,overweight,obese,found,much,stronger,Furthermore,interaction,body,mass,Conclusion
AB值：
0.390601
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
