典型文献
A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats
文献摘要：
Brain lesions can cause neural stem cells to activate, proliferate, differentiate, and migrate to the injured area. However, after traumatic brain injury, brain tissue defects and microenvironment changes greatly affect the survival and growth of neural stem cells; the resulting reduction in the number of neural stem cells impedes effective repair of the injured area. Melatonin can promote the survival, proliferation, and differentiation of neural stem cells under adverse conditions such as oxidative stress or hypoxia that can occur after traumatic brain injury. Therefore, we investigated the therapeutic effects of melatonin combined with neural stem cells on traumatic brain injury in rats. First, in vitro studies confirmed that melatonin promoted the survival of neural stem cells deprived of oxygen and glucose. Then, we established a three-dimensional Matrigel-based transplantation system containing melatonin and neural stem cells and then used it to treat traumatic brain injury in rats. We found that treatment with the Matrigel system containing melatonin and neural stem cells decreased brain lesion volume, increased the number of surviving neurons, and improved recovery of neurological function compared with treatment with Matrigel alone, neural stem cells alone, Matrigel and neural stem cells combined, and Matrigel and melatonin combined. Our findings suggest that the three-dimensional Matrigel-based transplantation system containing melatonin and neural stem cells is a potential treatment for traumatic brain injury.
文献关键词：
中图分类号：
作者姓名：
Xuan-Yu Fang;Da-Wei Zhao;Chao Zhang;Hong-Fei Ge;Xu-Yang Zhang;Feng-Chun Zhao;Yi-Bin Jiang;Hua Feng;Rong Hu
作者机构：
Department of Neurosurgery and Key Laboratory of Neurotrauma,Southwest Hospital,Army Medical University,Chongqing,China
文献出处：
引用格式：
[1]Xuan-Yu Fang;Da-Wei Zhao;Chao Zhang;Hong-Fei Ge;Xu-Yang Zhang;Feng-Chun Zhao;Yi-Bin Jiang;Hua Feng;Rong Hu-.A three-dimensional matrix system containing melatonin and neural stem cells repairs damage from traumatic brain injury in rats)[J].中国神经再生研究（英文版）,2022(11):2512-2517
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AB值：
0.436646
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