典型文献
New idea to promote the clinical applications of stem cells or their extracellular vesicles in central nervous system disorders:Combining with intranasal delivery
文献摘要：
The clinical translation of stem cells and their extracellular vesicles(EVs)-based therapy for central nervous system(CNS)diseases is booming.Nevertheless,the insufficient CNS delivery and reten-tion together with the invasiveness of current administration routes prevent stem cells or EVs from fully exerting their clinical therapeutic potential.Intranasal(IN)delivery is a possible strategy to solve prob-lems as IN route could circumvent the brain-blood barrier non-invasively and fit repeated dosage regi-mens.Herein,we gave an overview of studies and clinical trials involved with IN route and discussed the possibility of employing IN delivery to solve problems in stem cells or EVs-based therapy.We reviewed relevant researches that combining stem cells or EVs-based therapy with IN administration and analyzed benefits brought by IN route.Finally,we proposed possible suggestions to facilitate the development of IN delivery of stem cells or EVs.
文献关键词：
中图分类号：
作者姓名：
Yaosheng Li;Honghui Wu;Xinchi Jiang;Yunfei Dong;Juanjuan Zheng;Jianqing Gao
作者机构：
Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine,Zhejiang University,Hangzhou 310058,China;Hangzhou Institute of Innovative Medicine,Zhejiang University,Hangzhou 310058,China
文献出处：
引用格式：
[1]Yaosheng Li;Honghui Wu;Xinchi Jiang;Yunfei Dong;Juanjuan Zheng;Jianqing Gao-.New idea to promote the clinical applications of stem cells or their extracellular vesicles in central nervous system disorders:Combining with intranasal delivery)[J].药学学报（英文版）,2022(08):3215-3232
A类：
Intranasal,regi
B类：
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AB值：
0.506404
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