典型文献
CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation
文献摘要：
Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments,topologically associating domains and loops.The canonical CTCF-mediated loop extrusion model can explain the formation of loops.However,the organization mechanisms underlying long-range chromatin interactions such as interactions between A-A compartments are still poorly understood.Here we show that different from the canonical loop extrusion model,RYBP-mediated phase separation of CTCF organizes inter-A compartment interactions.Based on this model,we designed and verified an induced CTCF phase separation system in embryonic stem cells(ESCs),which facilitated inter-A compartment interactions,improved self-renewal of ESCs and inhibited their differentiation toward neural progenitor cells.These findings support a novel and non-canonical role of CTCF in organizing long-range chromatin interactions via phase separation.
文献关键词：
中图分类号：
作者姓名：
Chao Wei;Lumeng Jia;Xiaona Huang;Jin Tan;Mulan Wang;Jing Niu;Yingping Hou;Jun Sun;Pengguihang Zeng;Jia Wang;Li Qing;Lin Ma;Xinyi Liu;Xiuxiao Tang;Fenjie Li;Shaoshuai Jiang;Jingxin Liu;Tingting Li;Lili Fan;Yujie Sun;Juntao Gao;Cheng Li;Junjun Ding
作者机构：
RNA Biomedical Institute,Sun Yat-Sen Memorial Hospital,Zhongshan School of Medicine,Sun Yat-Sen University,Guangzhou,Guangdong,China;Advanced Medical Technology Center,The First Affiliated Hospital,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong,China;Center for Stem Cell Biology and Tissue Engineering,Key Laboratory for Stem Cells and Tissue Engineering,Ministry of Education,Zhongshan School of Medicine,Sun Yat-Sen University,Guangzhou,Guangdong,China;School of Life Sciences,Peking University,Beijing,China;School of Medicine,Tsinghua University,Beijing,China;Peking-Tsinghua Center for Life Sciences;Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,China;Department of Cell Biology,School of Basic Medical Sciences,Southern Medical University,Guangzhou,Guangdong,China;Department of Pediatric Surgery,Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong,China;State Key Laboratory of Proteomics,National Center of Biomedical Analysis,Institute of Basic Medical Sciences,Beijing,China;Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Jinan University,Guangzhou,Guangdong,China;State Key Laboratory of Membrane Biology,Biomedical pioneering innovation center(BIOPIC),Peking University,Beijing,China;MOE Key Laboratory of Bioinformatics;Bioinformatics Division,BNRist;Department of Automation;Center for Synthetic&Systems Biology,Tsinghua University,Beijing,China;Center for Bioinformatics,Center for Statistical Science,Peking University,Beijing,China
文献出处：
引用格式：
[1]Chao Wei;Lumeng Jia;Xiaona Huang;Jin Tan;Mulan Wang;Jing Niu;Yingping Hou;Jun Sun;Pengguihang Zeng;Jia Wang;Li Qing;Lin Ma;Xinyi Liu;Xiuxiao Tang;Fenjie Li;Shaoshuai Jiang;Jingxin Liu;Tingting Li;Lili Fan;Yujie Sun;Juntao Gao;Cheng Li;Junjun Ding-.CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation)[J].细胞研究（英文版）,2022(08):744-760
A类：
RYBP
B类：
CTCF,organizes,interactions,through,dependent,phase,separation,Chromatin,spatially,organized,into,three,dimensional,structures,levels,including,compartments,topologically,associating,domains,loops,canonical,mediated,extrusion,model,explain,formation,However,organization,mechanisms,underlying,long,range,chromatin,such,between,are,still,poorly,understood,Here,show,that,from,Based,this,designed,verified,induced,system,embryonic,cells,ESCs,which,facilitated,improved,self,renewal,inhibited,their,differentiation,toward,neural,progenitor,These,findings,support,novel,role,organizing,via
AB值：
0.541075
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