Mechanisms of homeostatic plasticity promote compensatory changes of cellular excitability in response to chronic changes in the network activity. This type of plasticity is essential for the maintenance of brain circuits and is involved in the regulation of neural regeneration and the progress of neurodegenerative disorders. One of the most studied homeostatic processes is synaptic scaling, where global synaptic adjustments take place to restore the neuronal firing rate to a physiological range by the modulation of synaptic receptors, neurotransmitters, and morphology. However, despite the comprehensive literature on the electrophysiological properties of homeostatic scaling, less is known about the structural adjustments that occur in the synapses and dendritic tree. In this study, we performed a meta-analysis of articles investigating the effects of chronic network excitation (synaptic downscaling) or inhibition (synaptic upscaling) on the dendritic spine density of neurons. Our results indicate that spine density is consistently reduced after protocols that induce synaptic scaling, independent of the intervention type. Then, we discuss the implication of our findings to the current knowledge on the morphological changes induced by homeostatic plasticity.

Thiago C.Moulin

Functional Pharmacology Unit,Department of Neuroscience,Uppsala University,Uppsala,Sweden;Institute of Medical Biochemistry,Federal University of Rio de Janeiro,Rio de Janeiro,Brazil;Institute of Biomedical Sciences,Federal University of Rio de Janeiro,Rio de Janeiro,Brazil;Department of Ophthalmology and Visual Sciences,Albert Einstein College of Medicine,NY,USA;Institute for Translational Medicine and Biotechnology,Sechenov First Moscow State Medical University,Moscow,Russia

中国神经再生研究（英文版）

[1]Thiago C.Moulin-.Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies)[J].中国神经再生研究（英文版）,2022(01):20-24

upscaling

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