典型文献
Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation
文献摘要：
In response to stimuli,the immediate early gene product Arc can acutely down-regulate synaptic strength by removing AMPA receptors(AMPARs)from synapses and thus regulate synaptic plasticity.How Arc,a scaffold protein,can specifically facilitate synaptic removal of AMPARs is unknown.We found that Arc directly antagonizes with PSD-95 in binding to TARPs,which are the auxiliary subunits of AMPARs.Arc,in a highly concentration-sensitive manner,acutely disperses TARPs from the postsynaptic density(PSD)condensate formed via phase separation.TARPs with the Ser residue in the"P-S-Y"-motif of its tail phosphorylated are completely refractory from being dispersed by Arc,suggesting that Arc cannot displace AMPARs from PSDs in active synapses.Conversely,strengthening the interaction between Arc and TARPs enhances Arc's capacity in weakening synapses.Thus,Arc can specifically and effectively modulate synaptic AMPAR clustering via modulating PSD phase separation.Our study further suggests that activity-dependent,bi-directional modulation of PSD condensate formation/dispersion represents a general regulatory mechanism for synaptic plasticity.
文献关键词：
中图分类号：
作者姓名：
Xudong Chen;Bowen Jia;Yoichi Araki;Bian Liu;Fei Ye;Richard Huganir;Mingjie Zhang
作者机构：
Division of Life Science,Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,China;Department of Neuroscience and Kavli Neuroscience Discovery Institute,Johns Hopkins University School of Medicine,Baltimore,MD,USA;School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,China
文献出处：
引用格式：
[1]Xudong Chen;Bowen Jia;Yoichi Araki;Bian Liu;Fei Ye;Richard Huganir;Mingjie Zhang-.Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation)[J].细胞研究（英文版）,2022(10):914-930
A类：
TARPs
B类：
Arc,weakens,synapses,by,dispersing,receptors,from,postsynaptic,density,via,modulating,phase,separation,In,response,stimuli,immediate,early,product,acutely,down,regulate,removing,AMPARs,thus,plasticity,How,scaffold,protein,specifically,facilitate,removal,unknown,We,found,that,directly,antagonizes,binding,which,are,auxiliary,subunits,highly,concentration,sensitive,manner,disperses,condensate,formed,Ser,residue,motif,tail,phosphorylated,completely,refractory,being,dispersed,suggesting,cannot,displace,PSDs,active,Conversely,strengthening,interaction,between,enhances,capacity,weakening,Thus,effectively,modulate,clustering,Our,study,further,suggests,activity,dependent,directional,modulation,formation,dispersion,represents,general,regulatory,mechanism
AB值：
0.523458
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
