典型文献
Effect of disrupted episodic memory on food consumption:no impact of neuronal loss of endophilin A1 on food intake and energy balance
文献摘要：
Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic drivers.Information from individuals with memory dysfunction suggests that episodic memory may also play a significant role.We reasoned that if memory influences food intake,then disrupting a genetic factor that is important in episodic memory formation should affect food intake and energy balance.We performed spatial learning tests on neuronal specific endophilin A1(EENA1)KO mice using the four-arm baited version of the radial arms maze(RAM).Energy regulation has also been evaluated.As anticipated neuronal EENA1 KO mice had impaired spatial memory.However,loss of endophilin A1 did not result in greater food intake,or altered energy absorption efficiency,relative to wild-type(WT)mice,when fed either low or high fat diets.Moreover,loss of EENA1 did not significantly affect other features of energy balance-physical activity and energy expenditure.No statistically significant changes were observed in the expression of hypothalamic neuropeptides related to food intake regulation,or circulating levels of leptin.We conclude that food intake and energy balance are largely governed by homeostatic and hedonic processes,and when these pro-cesses are intact memory probably plays a relatively minor role in food intake regulation.
文献关键词：
中图分类号：
作者姓名：
Jacques Togo;Yanrui Yang;Sumei Hu;Jia-Jia Liu;John R.Speakman
作者机构：
State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Shijingshan District,Beijing 100049,China;CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;CAS Center of Excellence for Animal Evolution and Genetics,Kunming,Yunnan 650223,China
文献出处：
引用格式：
[1]Jacques Togo;Yanrui Yang;Sumei Hu;Jia-Jia Liu;John R.Speakman-.Effect of disrupted episodic memory on food consumption:no impact of neuronal loss of endophilin A1 on food intake and energy balance)[J].遗传学报,2022(04):329-337
A类：
endophilin,reasoned,EENA1,baited
B类：
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AB值：
0.523955
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