典型文献
N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis
文献摘要：
Individual differences in the development of uncontrollable fear in response to traumatic stressors have been observed in clinic,but the underlying mechanisms remain unknown.In the present study we first conducted a meta-analysis of published clinical data and found that malondialdehyde,an oxidative stress biomarker,was significantly elevated in the blood of patients with fear-related anxiety disorders.We then carried out experimental study in rats subjected to fear conditioning.We showed that reestablishing redox homeostasis in basolateral amygdale(BLA)after exposure to fear stressors determined the capacity of learned fear inhibition.Intra-BLA infusion of buthionine sulfoximine(BSO)to deplete the most important endogenous antioxidant glutathione(GSH)blocked fear extinction,whereas intra-BLA infusion of dithiothreitol or N-acetylcysteine(a precursor of GSH)facilitated extinction.In electrophysiological studies conducted on transverse slices,we showed that fear stressors induced redox-dependent inhibition of NMDAR-mediated synaptic function,which was rescued by extinction learning or reducing agents.Our results reveal a novel pharmacological strategy for reversing impaired fear inhibition and highlight the role of GSH in the treatment of psychiatric disorders.
文献关键词：
中图分类号：
作者姓名：
Peng-fei Wu;Xin-lei Guan;Fang Wang;Jian-guo Chen
作者机构：
Department of Pharmacology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Key Laboratory of Neurological Diseases(HUST),Ministry of Education of China,Wuhan 430030,China;The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province,Wuhan 430030,China;Laboratory of Neuropsychiatric Diseases,The Institute of Brain Research,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Pharmacy,Wuhan Fourth Hospital,The Puai Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
文献出处：
引用格式：
[1]Peng-fei Wu;Xin-lei Guan;Fang Wang;Jian-guo Chen-.N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis)[J].中国药理学报（英文版）,2022(02):260-272
A类：
cued,reestablishing,amygdale,buthionine
B类：
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AB值：
0.603508
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