典型文献
Development of functional connectome gradients during childhood and adolescence
文献摘要：
Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cog-nition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitu-dinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in pri-mary and default-mode regions.These gradient changes are mediated by developmental changes in net-work integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.
文献关键词：
中图分类号：
作者姓名：
Yunman Xia;Mingrui Xia;Jin Liu;Xuhong Liao;Tianyuan Lei;Xinyu Liang;Tengda Zhao;Ziyi Shi;Lianglong Sun;Xiaodan Chen;Weiwei Men;Yanpei Wang;Zhiying Pan;Jie Luo;Siya Peng;Menglu Chen;Lei Hao;Shuping Tang;Jia-Hong Gao;Shaozheng Qin;Gaolang Gong;Sha Tao;Qi Dong;Yong He
作者机构：
State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing 100875,China;Beijing Key Laboratory of Brain Imaging and Connectomics,Beijing Normal University,Beijing 100875,China;IDG/McGovernn Institute for Brain Research,Beijing Normal University,Beijing 100875,China;School of Systems Science,Beijing Normal University,Beijing 100875,China;Center for MRI Research,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China;Beijing City Key Laboratory for Medical Physics and Engineering,Institute of Heavy Ion Physics,School of Physics,Peking University,Beijing 100871,China;Beijing Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China;IDG/McGovern Institute for Brain Research,Peking University,Beijing 100871,China;Chinese Institute for Brain Research,Beijing 102206,China
文献出处：
引用格式：
[1]Yunman Xia;Mingrui Xia;Jin Liu;Xuhong Liao;Tianyuan Lei;Xinyu Liang;Tengda Zhao;Ziyi Shi;Lianglong Sun;Xiaodan Chen;Weiwei Men;Yanpei Wang;Zhiying Pan;Jie Luo;Siya Peng;Menglu Chen;Lei Hao;Shuping Tang;Jia-Hong Gao;Shaozheng Qin;Gaolang Gong;Sha Tao;Qi Dong;Yong He-.Development of functional connectome gradients during childhood and adolescence)[J].科学通报（英文版）,2022(10):1049-1061
A类：
connectome,Connectome,transmodal
B类：
Development,functional,gradients,during,childhood,adolescence,mapping,studies,have,documented,principal,primary,adult,brain,network,capturing,spectrum,that,ranges,from,perception,action,abstract,nition,However,how,this,pattern,develops,whether,its,linked,cognitive,growth,topological,reorganization,expression,profiles,remain,largely,unknown,Using,longitu,dinal,resting,state,magnetic,resonance,imaging,data,children,aged,years,describe,substantial,changes,between,including,emergence,expansion,global,topography,focal,tuning,default,mode,regions,These,are,mediated,by,developmental,integration,segregation,associated,processing,functions,such,working,memory,levels,calcium,regulated,exocytosis,synaptic,transmission,related,genes,Our,findings,implications,understanding,maturation,principles,normal,disorders
AB值：
0.642952
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
