典型文献
A GSH-depleted platinum(Ⅳ)prodrug triggers ferroptotic cell death in breast cancer
文献摘要：
Cisplatin is the first-line drug for treatment of various solid tumors including breast cancer due to the broad anti-tumor spectrum and strong anti-tumor effect.However,serious side effects and long-term medication of reduced sensitivity by high GSH in tumor cells have severely restricted its fur-ther clinical application.Herein,a GSH-depleted Pt(Ⅳ)prodrug(Platin B)based on cisplatin and 4-carboxylphenylboronic acid pinacol ester was prepared to solve the problems.As an excellent GSH scav-enger,4-carboxylphenylboronic acid pinacol ester could be activated by intracellular redox reactions to release quinone methide,thereby amplifying oxidative stress and leading to breast cancer ferroptosis therapy.Interestingly,the consumption of GSH can also reduce cisplatin inactivation,enhance the sen-sitivity of tumor cells to cisplatin and efficiently induce apoptosis/ferroptosis.This work highlights the use of GSH scavenger for triggering ferroptotic cell death in breast cancer.
文献关键词：
中图分类号：
作者姓名：
Dachuan Qi;Lei Xing;Lijun Shen;Wenshuang Sun;Cheng Cai;Chunhua Xue;Xuwei Song;Hua Yu;Hulin Jiang;Chengjun Li;Qingri Jin;Zhiqi Zhang
作者机构：
Department of General Surgery,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai 200434,China;Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,China;Department of Orthopedics,Jinling Hospital,School of Medicine,Nanjing University,Nanjing 210002,China;Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province,College of Animal Science and Technology,College of Veterinary Medicine,Zhejiang A&F University,Lin'an 311300,China
文献出处：
引用格式：
[1]Dachuan Qi;Lei Xing;Lijun Shen;Wenshuang Sun;Cheng Cai;Chunhua Xue;Xuwei Song;Hua Yu;Hulin Jiang;Chengjun Li;Qingri Jin;Zhiqi Zhang-.A GSH-depleted platinum(Ⅳ)prodrug triggers ferroptotic cell death in breast cancer)[J].中国化学快报（英文版）,2022(10):4595-4599
A类：
Platin,carboxylphenylboronic,pinacol,scav,enger,methide
B类：
GSH,depleted,platinum,prodrug,triggers,ferroptotic,death,breast,cancer,Cisplatin,first,line,treatment,various,solid,tumors,including,due,broad,anti,spectrum,strong,However,serious,side,effects,long,term,medication,reduced,sensitivity,cells,have,severely,restricted,its,fur,clinical,application,Herein,Pt,cisplatin,acid,ester,was,prepared,solve,problems,excellent,could,be,activated,intracellular,redox,reactions,release,quinone,thereby,amplifying,oxidative,stress,leading,ferroptosis,therapy,Interestingly,consumption,also,inactivation,enhance,efficiently,induce,apoptosis,This,work,highlights,use,scavenger,triggering
AB值：
0.540462
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
