典型文献
Rhodium(Ⅲ)-catalyzed benzo[c]azepine-1,3(2H)-dione synthesis via tandem C-H alkylation and intermolecular amination of N-methoxylbenzamide with 3-bromo-3,3-difluoropropene
文献摘要：
Here,a rhodium(Ⅲ)-catalyzed benzo[c]azepine-1,3(2H)-dione synthesis via tandem C-H alkylation and intramolecular amination of N-methoxylbenzamide with 3-bromo-3,3-difluoropropene as the alkylation agent is reported.The substituted benzamides and protected indoles are all tolerated,yielding the cor-responding products in moderate to good yields.Further study revealed those bioactive compounds such as piperic acid and a key precursor of Roflumilast all perform well,highlighting the synthetic utility of this method.
文献关键词：
中图分类号：
作者姓名：
Xu Xu;Guanyu Zhou;Guodong Ju;Dongjie Wang;Bao Li;Yingsheng Zhao
作者机构：
Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical,Engineering and Materials Science,Soochow University,Suzhou 215123,China;School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453000,China
文献出处：
引用格式：
[1]Xu Xu;Guanyu Zhou;Guodong Ju;Dongjie Wang;Bao Li;Yingsheng Zhao-.Rhodium(Ⅲ)-catalyzed benzo[c]azepine-1,3(2H)-dione synthesis via tandem C-H alkylation and intermolecular amination of N-methoxylbenzamide with 3-bromo-3,3-difluoropropene)[J].中国化学快报（英文版）,2022(02):847-850
A类：
azepine,methoxylbenzamide,difluoropropene,benzamides,piperic,Roflumilast
B类：
Rhodium,catalyzed,benzo,2H,dione,synthesis,via,tandem,alkylation,intermolecular,amination,bromo,Here,rhodium,intramolecular,agent,reported,substituted,protected,indoles,are,all,tolerated,yielding,cor,responding,products,moderate,good,yields,Further,study,revealed,those,bioactive,compounds,such,acid,key,precursor,perform,well,highlighting,synthetic,utility,this,method
AB值：
0.549419
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