典型文献
Practical and modular construction of benzo[c]phenanthridine compounds
文献摘要：
Here,we describe a general and modular strategy for the rapid assembly of benzo[c]phenanthridine(BCP)derivatives using homogeneous gold catalysis.Notably,in contrast to traditional methods based on the specially preformed substrates that have an inherent preference for the formation of this class of compounds with limited flexibility,this protocol is achieved via a selectively intramolecular cascade of a diazo-tethered alkyne and subsequently an intermolecular cyclization with a nitrile to facilitate the successive C-N and C-C bonds formation.This methodology uses readily available nitriles as the nitrogen source to deliver the products in good yield with excellent functional group compatibility.A preliminary anti-tumor activity study of these generated products exhibits high anticancer potency against five tumor cell lines,including HeLa,Me1624,SW-480,8505C,LAN-1.Besides,we report a catalyst-controlled intermolecular cycloaddition/intramolecular insertion of the substrate with a fulvene to provide fused polycarbocycles containing a seven-membered ring.
文献关键词：
中图分类号：
作者姓名：
Cheng Zhang;Qian Chen;Lei Wang;Qiaoying Sun;Yangyang Yang;Matthias Rudolph;Frank Rominger;A.Stephen K.Hashmi
作者机构：
Organisch-Chemisches Institut,Heidelberg University,Heidelberg 69120,Germany;Cellular Immunotherapy Lab,the Medical Faculty of Heidelberg University,Heidelberg University Hospital,Heidelberg 69120,Germany;Chemistry Department,Faculty of Science,King Abdulaziz University(KAU),Jeddah 21589,Saudi Arabia
文献出处：
引用格式：
[1]Cheng Zhang;Qian Chen;Lei Wang;Qiaoying Sun;Yangyang Yang;Matthias Rudolph;Frank Rominger;A.Stephen K.Hashmi-.Practical and modular construction of benzo[c]phenanthridine compounds)[J].中国科学:化学（英文版）,2022(07):1338-1346
A类：
phenanthridine,nitriles,Me1624,8505C,fulvene,polycarbocycles
B类：
Practical,modular,construction,benzo,compounds,Here,we,describe,general,strategy,rapid,assembly,BCP,derivatives,using,homogeneous,gold,catalysis,Notably,contrast,traditional,methods,specially,preformed,substrates,that,have,inherent,preference,formation,this,class,limited,flexibility,protocol,achieved,via,selectively,intramolecular,cascade,diazo,tethered,alkyne,subsequently,intermolecular,cyclization,facilitate,successive,bonds,This,methodology,uses,readily,available,nitrogen,source,deliver,products,good,yield,excellent,functional,group,compatibility,preliminary,tumor,activity,study,these,generated,exhibits,high,anticancer,potency,against,five,lines,including,HeLa,SW,LAN,Besides,report,catalyst,controlled,cycloaddition,insertion,provide,fused,containing,seven,membered,ring
AB值：
0.681393
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