典型文献
In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography
文献摘要：
Covalent organic frameworks(COFs)are a novel type of crystalline porous organic polymer materials recently developed.It has several advantages in chromatographic separation field,such as high thermal stability,porosity,structural regularity,and large specific surface area.Here,a novel spherical COF 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,5-bis(2-propyn-1-yloxy)-1,4-benzenedicarboxaldehyde(BPTA)was developed as an electrochromatographic stationary phase for capillary electro-chromatography separation.The COFTTAPB-BPTA modified capillary column was fabricated via a facile in situ growth method at room temperature.The characterization results of scanning electron microscopy(SEM),Fourier transform infrared(FT-IR)spectroscopy,and X-ray diffraction(XRD)confirmed that COF TAPB-BPTA were successfully modified onto the capillary inner surface.The electrochromatography separation performance of the COF TAPB-BPTA modified capillary was investigated.The prepared column demonstrated outstanding separation performance toward alkylbenzenes,phenols,and chlorobenzenes compounds.Furthermore,the baseline separations of non-steroidal anti-inflammatory drugs(NSAIDs)and parabens with good efficiency and high resolution were achieved.Also,the prepared column possessed satisfactory precision of the intra-day runs(n=5),inter-day runs(n=3),and parallel columns(n=3),and the relative standard deviations(RSDs)of the retention times of tested alkylbenzenes were all less than 2.58％.Thus,this new COF-based stationary phase shows tremendous application potential in chromatographic separation field.
文献关键词：
中图分类号：
作者姓名：
Ning He;Zhentao Li;Changjun Hu;Zilin Chen
作者机构：
Department of Orthopedics Trauma and Microsurgery,Zhongnan Hospital of Wuhan University,School of Pharmaceutical Sciences,Wuhan University,Wuhan,430072,China;Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals,Wuhan,430071,China
文献出处：
引用格式：
[1]Ning He;Zhentao Li;Changjun Hu;Zilin Chen-.In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography)[J].药物分析学报（英文）,2022(04):610-616
A类：
propyn,yloxy,benzenedicarboxaldehyde,BPTA,electrochromatographic,COFTTAPB,alkylbenzenes,chlorobenzenes
B类：
In,situ,synthesis,spherical,covalent,organic,stationary,phase,capillary,electrochromatography,Covalent,frameworks,COFs,novel,type,crystalline,porous,polymer,materials,recently,developed,It,several,advantages,field,such,high,thermal,stability,porosity,structural,regularity,large,specific,surface,area,Here,tris,aminophenyl,bis,was,modified,fabricated,facile,growth,method,room,temperature,characterization,results,scanning,electron,microscopy,Fourier,transform,infrared,spectroscopy,ray,diffraction,confirmed,that,were,successfully,onto,inner,performance,investigated,prepared,demonstrated,outstanding,toward,phenols,compounds,Furthermore,baseline,separations,steroidal,anti,inflammatory,drugs,NSAIDs,parabens,good,efficiency,resolution,achieved,Also,possessed,satisfactory,precision,intra,day,runs,inter,parallel,columns,relative,standard,deviations,RSDs,retention,times,tested,less,than,Thus,this,new,shows,tremendous,application,potential
AB值：
0.526443
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