典型文献
Overcoming antibiotic resistance through efficient and scalable total synthesis
文献摘要：
Bacterial ribosome has served as an important target for antibiotics that are essential to public health,such as erythromycins,tetracyclines,amino-glycosides,pleuromutilin and fusidic acid,all with natural origin[1].The structural complexity of these natural products has posed significant chal-lenges to total synthesis,especially in an efficient and scalable manner,hence their semi-synthetic analogs dominating the clinical setting.The scenario has undergone a paradigm shift over recent years,starting with the landmark work on tetracyclines reported by Myers'group,which led to novel analogs via de novo total synthesis[2].
文献关键词：
中图分类号：
作者姓名：
Yang Jiao;Tuoping Luo
作者机构：
Key Laboratory of Bioorganic Chemistry and Molecular Engineering,Ministry of Education and Beijing National Laboratory for Molecular Science,College of Chemistry and Molecular Engineering,Peking University,China;Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Peking University,China;Institute of Molecular Physiology,Shenzhen Bay Laboratory,China
文献出处：
引用格式：
[1]Yang Jiao;Tuoping Luo-.Overcoming antibiotic resistance through efficient and scalable total synthesis)[J].国家科学评论（英文版）,2022(11):2-3
A类：
erythromycins,pleuromutilin,fusidic
B类：
Overcoming,resistance,through,efficient,scalable,total,synthesis,Bacterial,ribosome,has,served,important,target,antibiotics,that,are,essential,public,health,such,tetracyclines,amino,glycosides,acid,natural,origin,structural,complexity,these,products,posed,significant,chal,lenges,especially,manner,hence,their,semi,synthetic,analogs,dominating,clinical,setting,scenario,undergone,paradigm,shift,over,recent,years,starting,landmark,work,reported,by,Myers,group,which,led,novel,via,novo
AB值：
0.677133
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
