High mobility group box 1(HMGB1)is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings.Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response,immune reactions,cell migration,aging,and cell death.Sepsis is a systemic inflammatory response syndrome(SIRS)that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide,particularly in the aging population.Dysregulated systemic inflammation is a classic characteristic of sepsis,and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes.Here,we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury,the ways by which HMGB1 are released,and the signaling pathways and therapeutics associated with HMGB1.This review highlights recent advances related to HMGB1:the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury.

Chao Deng;Lin Zhao;Zhi Yang;Jia-jia Shang;Chang-yu Wang;Ming-zhi Shen;Shuai Jiang;Tian Li;Wen-cheng Di;Ying Chen;He Li;Ye-dong Cheng;Yang Yang

Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases,Xi'an No.3 Hospital,School of Life Sciences and Medicine,Northwest University,Xi'an 710021,China;Department of Orthopaedics,Huaian Medical District of Jingling Hospital,Medical School of Nanjing University,Huaian 213001,China;Department of Cardiovascular Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Department of Cardiovascular Surgery,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032,China;Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education.Life of Sciences,Northwest University,Xi'an 710021,China;Department of Cardiology,Xi'an No.3 Hospital,School of Life Sciences and Medicine,Northwest University,Xi'an 710021,China;Hainan Hospital of PLA General Hospital,The Second School of Clinical Medicine,Southern Medical University,Sanya 572013,China;National Clinical Research Center for Infectious Diseases,Shenzhen Third People's Hospital,Southern University of Science and Technology,Shenzhen 518100,China;Department of Hematology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China

中国药理学报（英文版）

[1]Chao Deng;Lin Zhao;Zhi Yang;Jia-jia Shang;Chang-yu Wang;Ming-zhi Shen;Shuai Jiang;Tian Li;Wen-cheng Di;Ying Chen;He Li;Ye-dong Cheng;Yang Yang-.Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury)[J].中国药理学报（英文版）,2022(03):520-528

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