典型文献
Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma
文献摘要：
Proteins are key players in various cellular processes. As the ultimate executors of cellular processes, they play essen-tial roles in linking genotypes to phenotypes. Abnormalities in protein expression and post-translational modifications (PTMs) are closely associated with the initiation and devel-opment of cancer, and they carry biological information inaccessible to genomics and transcriptomics1. Proteomics complements genomic and transcriptomic data, thus ena-bling comprehensive analysis of cancer pathogenesis and accelerating biomedical research2. Owing to the limitations of protein quantification instrumentation and methods, the development of proteomics has substantially lagged behind that of genomics and transcriptomics. Fortunately, recent technological advances in mass spectrometry-based proteom-ics have substantially increased the number of proteins that can be quantified (at high resolution) and the number of samples that can be profiled within a reasonable time frame (high throughput)3. Consequently, whole proteome quantifi-cation can now be performed on a large scale, thereby enabling proteome characterization with greater statistical significance, identification of proteomic subtypes, and discovery of poten-tial drugs. We refer to the high-resolution, high-throughput proteomics profiling of large-scale samples as deep proteome profiling.
文献关键词：
中图分类号：
作者姓名：
Wei Liu;Yongping Cui;Wen Liu;Zhihua Liu;Liyan Xu;Enmin Li
作者机构：
College of Science,Heilongjiang Institute of Technology,Harbin 150050,China;Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology,the Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area,Shantou University Medical College,Shantou 515041,China;Department of Pathology,Key Laboratory of Cellular Physiology(Shanxi Medical University),Ministry of Education,Taiyuan 030001,China;Fujian Provincial Key Laboratory of Innovative Drug Target Research,School of Pharmaceutical Sciences,Xiamen University,Xiamen 361005,China;State Key Lab of Molecular Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
文献出处：
引用格式：
[1]Wei Liu;Yongping Cui;Wen Liu;Zhihua Liu;Liyan Xu;Enmin Li-.Deep proteome profiling promotes whole proteome characterization and drug discovery for esophageal squamous cell carcinoma)[J].癌症生物学与医学（英文版）,2022(03):273-277
A类：
executors,transcriptomics1,research2,proteom
B类：
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AB值：
0.554852
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