Bone is a connective tissue that has important functions in the human body. Cells and the extracellular matrix (ECM) are key components of bone and are closely related to bone-related diseases. However, the outcomes of conventional treatments for bone-related diseases are not promising, and hence it is necessary to elucidate the exact regulatory mechanisms of bone-related diseases and identify novel biomarkers for diagnosis and therapy. Circular RNAs (circRNAs) are single-stranded RNAs that form closed circular structures without a 5' cap or 3' tail and polycyclic adenylate tails. Due to their high stability, circRNAs have the potential to be typical biomarkers. Accumulating evidence suggests that circRNAs are involved in bone-related diseases, including osteoarthritis, osteoporosis, osteosarcoma, multiple myeloma, intervertebral disc degeneration, and rheumatoid arthritis. Herein, we summarize the recent research progress on the characteristics and functions of circRNAs, and highlight the regulatory mechanism of circRNAs in bone-related diseases.

Linghui HU;Wei WU;Jun ZOU

School of Exercise and Health,Shanghai University of Sport,Shanghai 200438,China

浙江大学学报（英文版）（B辑：生物医学和生物技术）

[1]Linghui HU;Wei WU;Jun ZOU-.Circular RNAs:typical biomarkers for bone-related diseases)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(12):975-988,中插1-中插6

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