典型文献
Comprehensive analysis identifies as a critical prognostic prediction gene in breast cancer
文献摘要：
Background::Aurora kinases
(AURKs) family plays a vital role not only in cell division but also in tumorigenesis. However, there are still rare systematic analyses of the diverse expression patterns and prognostic value of the
AURKs family in breast cancer (BC). Systematic bioinformatics analysis was conducted to explore the biological role, prognostic value, and immunologic function of
AURKs family in BC.
Methods::The expression, prognostic value, and clinical functions of
AURKs family in BC were evaluated with several bioinformatics web portals: ONCOMINE Gene Expression Profiling Interactive Analysis, Kaplan-Meier plotter, cBioPortal, Metascape, GeneMANIA, and LinkedOmics; and the result was verified using human tissues.
Results::The expression of
AURKA and
AURKB were upregulated in BC in subgroup analyses based on tumor stage (all
P < 0.05). BC patients with high
AURKA and
AURKB expression had a worse overall survival, relapse-free survival, and distant metastasis-free survival (all
P < 0.05). Verification experiment revealed that
AURKA and
AURKB were upregulated in BC (
P < 0.05).
AURKA and
AURKB were specifically associated with several tumor-associated kinases (polo-like kinase 1 and cyclin-dependent kinase 1), miRNAs (miR-507 and miR-381), and
E2F transcription factor 1. Moreover,
AURKA and
AURKB were correlated with immune cell infiltration. Functional enrichment analysis revealed that
AURKA and
AURKB were involved in the cell cycle signaling pathway, platinum drug resistance signaling pathway,
ErbB signaling pathway,
Hippo signaling pathway, and nucleotide-binding and oligomerization domain-like receptor signaling pathway.
Conclusions::Aurora kinases
AURKA and
AURKB could be employed as novel prognostic biomarkers or promising therapeutic targets for BC.
文献关键词：
Aurora kinases;AURKs;Breast cancer;Prognosis;Bioinformatics analysis
中图分类号：
作者姓名：
Hu Ting;Wang Xu;Xia Yun;Wu Lu;Ma Yuxi;Zhou Rui;Zhao Yanxia
作者机构：
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China
文献出处：
引用格式：
[1]Hu Ting;Wang Xu;Xia Yun;Wu Lu;Ma Yuxi;Zhou Rui;Zhao Yanxia-.Comprehensive analysis identifies as a critical prognostic prediction gene in breast cancer)[J].中华医学杂志（英文版）,2022(18):2218-2231
A类：
AURKs
B类：
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AB值：
0.530836
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